Two new cell lines with the phenotype of terminally differentiated B cells have been derived from the presentation bone marrow of a patient with plasma cell leukaemia. They express the same immunoglobulin (A1-kappa) as the original bone marrow cells. JJN-1 is an hypodiploid, slow-growing line...
Formed in 2014, HaemaLogiX is a public unlisted biotech company researching antibody therapies for multiple myeloma. Multiple myeloma is a haematological (blood) cancer of plasma cells (B cells) that can cause focused damage to a patient’s bone marrow. Multiple myeloma is considered treatable but...
Plasma cell myelomaPlasmacytomaSM-AHNMDAn association between mastocytosis and monoclonal gammopathy is a relatively rare but well recognized clinical finding. In the majority of cases, however, overt myeloma or lymphoma is not detectable morphologically. Here we describe the case of a 51 year-old ...
M protein is an immunoglobulin produced by monoclonal proliferation of plasma cells or B lymphocytes. There are four categories of M protein: malignant M protein, which is commonly seen in multiple myeloma(MM), heavy chain disease, malignant lymphoma, lymphocytic leukemia, macroglobulinemia, etc.; ...
multiple myeloma (MM), incurability remains an ongoing clinical challenge1. MM is characterised by the expansion of malignant monoclonal plasma cells (PCs) within the bone marrow (BM), and production of excess monoclonal immunoglobulin (M protein) and/or isotype-restricted free light chains (FLC)...
The case of a female patient with multiple myeloma in whom the circulating monoclonal protein was IgD with kappa light chains is presented. The case is ext... HC Ford,BR Casey,W Susan,... - 《American Journal of Clinical Pathology》 被引量: 6发表: 1980年 IgD/lambda plasmocytoma with im...
Monoclonal gammopathies result from an overproduction of a single abnormal clone of a plasma cell or B lymphocyte. The purpose of the laboratory protocols ... PV Bottini - 《Rev.bras.hematol.hemoter》 被引量: 7发表: 2007年 Aberrant expression of immunoglobulin light chain isotype in B lympho...
Multiple myeloma is a clonal malignant neoplasm of plasma cells and is characterized by the secretion of monoclonal protein in plasma. Here, we report a case of biclonal multiple myeloma having two spikes on serum protein electrophoresis, one being in Beta-2 region and the other in gamma region...
Class Monoclonal Type Antibody Full Name Human IgG Kappa chain Synonyms human IgG, Human IgG Kappa chain Calculated Molecular Weight 155 kDa Observed Molecular Weight ~25 kDa Gene Symbol Gene ID (NCBI) RRID AB_2920515 Conjugate HRP Form Liquid Purification Method Protein G purification Storage Bu...
Screening of SARS-CoV-2 inhibitors including small molecules, monoclonal antibodies, or convalescent plasma References: 1. Johnson, M.C.et al.2020.Optimized Pseudotyping Conditions for the SARS-COV-2 Spike Glycoprotein. J Virol 94. 2. Ou, X.et al.2020.Characterization of spike glycoprotein of ...