Therefore, it is probably prudent to avoid using the term monoclonal B-cells in a flow cytometric report, and instead use the more accurate term immunoglobulin light chain class restricted B-cells. In addition, some light chain restricted populations that are truly clonal are not neoplastic [17]...
and a broadly neutralizing V3-glycan-directed monoclonal antibody (mAb) BF520.1 was isolated ~1–6 years post infection (pi)19at 15 months of age. To infer the ontogeny of this bnAb, we performed next generation sequencing of the infant’s B-cell repertoire on an available post infection ...
Although a gene rearrangement corresponding to the minor -positive population was not detected, a small monoclonal (M) band of IgM- was present in the serum. The chromosome translocations and the pattern of light chain expression, particularly the -producing cells, are discussed in the light of ...
incurability remains an ongoing clinical challenge1. MM is characterised by the expansion of malignant monoclonal plasma cells (PCs) within the bone marrow (BM), and production of excess monoclonal immunoglobulin (M protein) and/or isotype-restricted free light chains (FLC)2,3. ...
Smoldering Multiple Myeloma (SMM) is defined as focal premalignant plasma cell proliferation in the bone marrow, along with the presence of monoclonal or b... B Mehrotra,AK Kapoor,RK Srivastava,... - 《Journal of Clinical & Diagnostic Research》 被引量: 0发表: 2023年 Immunoglobulin D-kappa ...
Phase 2a, Open-Label, Multi-Dose Study Of Anti-Kappa Monoclonal Antibody, MDX-1097, In Relapsed Kappa-Chain Restricted Multiple Myeloma With Stable Measura... A Spencer 被引量: 0发表: 0年 A phase I, open-label, dose-escalation, multidose study of MDX-1401 (defucosylated human antiCD30...
6. An antibody immunoreactive with a RANK polypeptide selected from the group consisting of: (a) a polypeptide of SEQ ID NO:6; and (b) a polypeptide of SEQ ID NO:15; optionally wherein the antibody is a monoclonal antibody. 7. The antibody of claim 6, for use in therapy or diagnos...
(Urban and Roth, 2015) and have been used to manipulate cell signaling within diverse cell types (Rogan and Roth, 2011). However, the dependency on the same chemical actuator clozapine-N-oxide (CNO) has restricted the ability to use DREADDs to selectively either inhibit or activate neuronal ...
Phase 2a, Open-Label, Multi-Dose Study Of Anti-Kappa Monoclonal Antibody, MDX-1097, In Relapsed Kappa-Chain Restricted Multiple Myeloma With Stable Measurable DiseaseAndrew Spencer
IEF is followed by silver staining or immunoblotting, whereby the presence of cerebrospinal fluid (CSF) restricted oligoclonal bands (OCB) indicates a central nervous system-specific B cell activation, which is a hallmark of various neuroimmunological diseases, including multiple sclerosis (MS) [1,...