Clonally restricted B cells in periph- eral blood of multiple sclerosis patients: kappa/lambda staining pat- terns. Ann Neurol 1982;11:408 - 412.Hauser, S.L., H.L. Weiner and K.A. Ault. Clonally restricted B cells in peripheral blood of multiple sclerosis patients: kappa/lambda staining ...
The presence of both kappa- and lambda-light chain-restricted B-cell populations in B-cell lymphomas, including MALT lymphoma, is an unusual findings [16]. Edinger et al. reported 2 other examples of primary cutaneous marginal zone lymphomas that express both kappa- and lambda-light chain-...
A pure population of light chain restricted B-cells is easy to recognize using flow cytometricimmunophenotypingand is usually reflected in an abnormal kappa/lambda ratio. However, evaluation of the kappa to lambda ratio will not identify small clonal populations admixed with reactive polyclonal B-cell...
Understanding which opioid receptors are expressed in which types of peripheral sensory neurons is important because this insight may inform the clinical use of peripherally restricted agonists. In the present study, we used the combination of a KOR-cre allele, viral tracing, single-cell RT-PCR, ...
Other more recent lines have CRF overexpression restricted to developmental time windows, brain regions, or cell types. Although CRF mRNA expression has been evaluated in several of these models, CRF immunoreactivity throughout the brain has not been examined or compared between models. Here we ...
Dendritic cells are referred to as "professional" antigen presenting cells, and have a high capacity for sensitizing MHC-restricted T cells. There is growing interest in using dendritic cells ex vivo as tumor or infectious disease vaccine adjuvants (see, for example, Romani, et al., J. Exp....
Thus, a course of plasticity induced by tDCS is still relatively restricted, advanced stimulation protocols are needed. Methods: For identifying pathological plasticity alterations in schizophrenia, tDCS was applied to the motor cortex of patients and healthy controls. tDCS-induced alterations of cortical...
NMDARs in Ih- neurons as well as a selective projection-specific KOR-induced increase in GABA release (or maybe reduced inhibitory effect of KOR on GABA release due to KOR's restricted expression on these terminals) could contribute to the net KOR-induced reduction of Ih- neuronal excitability...
drugs to inactivate NF-κB is currently a challenge, not only for the treatment of thyroid tumors but also for that of the majority of human cancers, so much so that the only anti-NF-κB drug approved in therapeutic regimens is bortezomib, whose employment is restricted to multiple myeloma....
IEF is followed by silver staining or immunoblotting, whereby the presence of cerebrospinal fluid (CSF) restricted oligoclonal bands (OCB) indicates a central nervous system-specific B cell activation, which is a hallmark of various neuroimmunological diseases, including multiple sclerosis (MS) [1,...