Plasma cell neoplasmMyelomaImmunophenotypingFlow cytometryMinimal residual diseasePrognosisPlasma cell neoplasms (PCN) are a heterogeneous group of disorders with a spectrum of clinical presentations from asymptomatic monoclonal gammopathy of undetermined significance (MGUS) to smoldering multiple myeloma to ...
Flow cytometry immunophenotyping (FCM) has become an integral part of diagnosis and management of patients with plasma cell neoplasms (PCN) and related diseases. Immunophenotypic profiles of neoplastic plasma cells (PCs) in PCN are distinct from that of benign or reactive PCs, and differs from ...
Optimisation of flow cytometry for the investigation of plasma cell dyscrasias Australian Journal of Medical ScienceIrwin, RebeccaLemmert, KarlaVanniasinkam, Thiru
摘要: SummaryIntroduction: Flow cytometry (FC) has become increasingly utilized in the diagnosis and monitoring of plasma cell myeloma (PCM), though few studies have evaluated the longitudinal stability of antigen expression.DOI: 10.1111/j.1751-553x.2011.01317.x 年份: 2011 ...
Flow cytometry is also useful in the diagnosis of plasma cell dyscrasias. Plasma cells areCD38+(bright) and CD138+(although less sensitive). Plasma cells in the blood andtonsilsare CD45+, whereas in the bone marrow plasma cells may be either CD45+positive or CD45−. Normal plasma cells...
Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry We have recently described a highly sensitive flow cytometric technique, based on the ability to detect single cell expression of cytokines, to simultaneou... MA Suni,LJ Picker,VC Maino - 《Journal of Immun...
f, Gating strategy for flow cytometric analysis of meningeal immune cell subsets following Bz treatment. g, Bar graph depicting the total cell counts of the indicated immune cell populations in Gel- or Bz-treated animals (mean \(\pm \) s.d., n = 4 mice per group; no statistically ...
Background Major heterogeneity between laboratories in flow cytometry (FC) minimal residual disease (MRD) testing in multiple myeloma (MM) must be overcome. Cytometry societies such as the International Clinical Cytometry Society and the European Society for Clinical Cell Analysis recognize a strong need...
Monitoring treatment response of childhood precursor B-cell acute lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with multiparameter flow cytome... Treatment response is a strong outcome predictor for childhood acute lymphoblastic leukemia (ALL). Here, we evaluated the predictive impact of ...
Taken together, this study demonstrates that 6-color flow cytometry is an excellent, cost-effective means to assay for clonal plasma cells in a noncontrolled patient population. 展开 关键词: Plasma cell myeloma Multiple myeloma Flow cytometry ...