plasma cell myelomaVS38cPlasma cell myeloma (multiple myeloma, MM) is a malignant neoplasm originating from the plasma cells. Besides other methods, flow cytometric (FCM) analysis of the patient's bone marrow aspirate has an important role in the diagnosis and also in the response assessment. ...
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147 Therefore, demonstration of monoclonality is required as per other MRDs (e.g., by flow cytometry, immunocytochemistry, cell block preparations for immunohistochemistry, or molecular techniques). It is classified as either primary PCL when it presents “de novo” in patients with no previous ...
P2RX4 promotes plasma cell survival by regulating endoplasmic reticulum homeostasis, as short-term P2RX4 blockade caused accumulation of endoplasmic reticulum stress-associated regulatory proteins including ATF4 and B-lineage mutation of the pro-apoptotic ATF4 target Chop prevented bone marrow plasma cell ...
Cytometry Part B Clinical CytometryPotential Therapeutic Targets in Plasma Cell Disorders:A Flow Cytometry Study. Lisenko K,Schonland S,Hegenbart U,et al. Cytometry B Clin Cytom . 2015Lisenko, K., S. Schonland, U. Hegenbart, K. Wallenwein, U. Braun, E. K. Mai, et al. 2015. ...
5 B cell expansion in meninges following systemic candidiasis. a, Representative flow cytometric plot of CD19+B220+CD79b+ meningeal B cells after intravenous administration of C. albicans, with a bar graph to the right depicting an increase in the total number of naive (IgD+IgM+) and class...
The nature of the antigen, BCR affinity, co-stimulatory signals during B-cell activation, and the B-cell subtype influence how B-cells differentiate towards plasma cells and might also affect the long-term fate of the resulting plasma cells. This differentiation can either be directly at ...
–Next-generation flow cytometry, PCR, and next-generation sequencing–based techniques are highly sensitive methods of assessing measurable residual disease, important for evaluating disease response and risk stratification following therapy. –Myeloma arises from premalignant states, initiated by primary cyto...
RPMI-8226 is a human myeloma cell line, which expresses high levels of CD138 molecules [16]. This CD138+ cell line was stained with the five mAbs and immediately analyzed by flow cytometry with or without fixation or after an overnight period following fixation (Table 1). All anti-CD138...
• The term “multiple myeloma” replaces the term “plasma cell myeloma” used in the 2016 WHO classification. • Multiple myeloma is subdivided into 4 mutually exclusive cytogenetic groups and MM NOS. • Minimal bone marrow infiltration detected by flow cytometry is of major prognostic impor...