Other less common categories of PCN include AL amyloidosis, POEMS syndrome, and plasma cell leukemia. Typically, the gold standard for diagnosis has been to correlate morphologic assessment with clinical information (hypercalcemia, renal failure, anemia, and lytic bone lesions) and serologic data, ...
Primary plasma cell leukemia (pPCL) is a rare and aggressive form of multiple myeloma (MM) that is characterized by the presence of ≥20% circulating plasma cells. Overall survival remains poor despite advances of anti-MM therapy. The disease biology as well as molecular mechanisms that distingui...
Primary plasma cell leukemia (pPCL) is a rare and aggressive plasma cell proliferative disorder with a very poor prognosis and with distinct biologic, clinical, and laboratory features. Compared with multiple myeloma, pPCL presents more often with extramedullary involvement, anemia, thrombocytopenia, hype...
Plasma cell leukemia (PCL) is a rare and aggressive form of plasma cell dyscrasia, often presenting as a variant of multiple myeloma (MM). It is characterized by the presence of ≥5% circulating plasma cells in peripheral blood, either as a primary or secondary manifestation of MM. METHODS...
Plasma cell leukemia Nonsecretory myeloma Solitary plasmacytoma Primary amyloidosis Heavy chain disease POEMS Adapted fromKyle RA, Rajkumar SV. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. Hematol Oncol Clin North Am 2007;21:1093. ...
Extensive flow cytometric characterization of plasmacytoid dendritic cell leukemia cells Objectives: Accumulating evidence suggests that non-T, non-B cell CD4+CD56+ neoplasms with lymphoblastic morphology include clinically and immunophenoty... Laszlo,Gopcsa,Aniko,... - 《European Journal of Haematology...
Unusual Case of Simultaneous Presentation of Plasma Cell Myeloma, Chronic Myelogenous Leukemia, and a Jak2 Positive Myeloproliferative Disorder There are currently no reported cases with the diagnosis of simultaneous plasma cell myeloma, chronic myelogenous leukemia, and Jak2 positive myeloproliferative disorder...
Phenotypic, molecular, and cellular genetic data favor the presence of a myeloma stem cell early in hematopoietic development so that, as in chronic myelogenous leukemia (CML), a far distance exists between the primordial malignant cell that was the target of malignant transformation and the ...
PC population is established, it has the potential to behave in many ways, not all of which will require treatment. Currently, there are several subtypes ofPCDs, including (1)monoclonal gammopathyof undetermined significance (MGUS), (2)asymptomatic myeloma, (3)multiple myeloma, (4)PC leukemia,...
& Amit, I. Single-cell genomics: a stepping stone for future immunology discoveries. Cell 172, 14–21 (2018). Article CAS PubMed Google Scholar Paiva, B. et al. Differentiation stage of myeloma plasma cells: biological and clinical significance. Leukemia 31, 382–392 (2017). Article CAS...