In biological systems, the bioavailability of drugs is determined by several parameters such as pKa values. In this study, we used DFT and thermodynamics cycle to determine pKa value of side chain of lysine in linear and cyclic dipeptides. All considered dipeptides were optimized using B3LYP and ...
Reductive methylation of lysine residues in proteins offers a way to introduce13C methyl groups into otherwise unlabeled molecules. The13C methyl groups on lysines possess favorable relaxation properties that allow highly sensitive NMR signal detection. One of the major limitations in the use of reduc...
cAMP-PKA signaling may induce ER stress, leading to autophagy-induced degradation of ferritin heavy chain 1, intracellular accumulation of Fe2+, and ferroptosis [49]. However, recent studies indicate that PKA may inhibit ER stress and ferroptosis ...
Equilibrium thermodynamic experiments showed that the Lys-66 mutant remained folded and native-like after ionization of the buried lysine. The high polarizability must therefore reflect water penetration, minor local structural rearrangement, or both. When in pKa calculations with continuum methods, the ...
Chain extension occurs via addition of subsequent ubiquitin molecules to either one of the seven lysine residues of ubiquitin, or via its N-terminal α-amino group to build linear ubiquitin chains. The pKa of lysine side chains is around 10.5 and hence E3 ligases require a mechanism to de...
For example, the residues histidine, lysine, and arginine are Lewis bases. This is because they can all donate a lone pair of electrons. Histidine from the non-delocalized lone pair on the imidazole side chain; lysine from the terminal amine group, and arginine from the guanidino group. ...
PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B Nat. Cell Biol., 13 (2011), pp. 668-675 CrossrefView in ScopusGoogle Scholar Bachmann et al., 2016 V.A. Bachmann, J.E. Mayrhofer, R. Ilouz, P. Tschaikner, P. Raffeiner, R. Rock, M. Courcelles, F....
The extracted DRG tissues were separated mechanically into pieces and dissociated into single cells with trypsin (0.125%) (Gibco, Grand Island, NY, U.S.). Then, the individual cells were seeded onto poly-L-lysine (Gibco, Grand Island, NY, U.S.)-coated plates for further study....
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presentation. A negative correlation was observed between allysine and all-trans-retinoic acid levels, whereas D-glucuronic acid and hexanoyl carnitine levels displayed a positive correlation with the modified Rodnan skin score (mRSS). The presence of interstitial lung disease (ILD) in systemic ...