Pioneer factors: nature or nurture?Shane StoeberHolly GodinCheng XuLu Bai
Pioneer factors are transcription factors with the unique ability to initiate opening of closed chromatin. The stability of cell identity relies on robust mechanisms that maintain the epigenome and chromatin accessibility to transcription factors. Pionee
Pioneer transcription factors direct cell differentiation by deploying new enhancer repertoires through their unique ability to target and initiate remodelling of closed chromatin. The initial steps of their action remain undefined, although pioneers have been shown to interact with nucleosomal target DNA an...
LETTERdoi:10.1038/nature14289Pioneerfactorsgovernsuper-enhancerdynamicsinstemcellplasticityandlineagechoiceReneC.Adam1,HanseulYang1,Sh..
Pioneer® brand 11B91 high-moisture corn inoculant is a nonhazardous biological solution to bunklife problems, helping avoid the use of expensive and caustic acid products. Next-generationLactobacillus buchneriimproves fermentation, retaining nutrient content and enhancing digestibility of ensiled high-moi...
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China 武汉英中高级中学(武外英中),中国 Pioneer research area: Environmental Studies 环境研究 Pioneer research concentration: Water Quality and Global Environmental Health Pioneer research topic: A Review of Non-classic Biomanipulation Experiments at Freshwater Lakes in China and the Factors that Influence ...
While most transcription factors exit the chromatin during mitosis and the genome becomes silent, a subset of factors remains and "bookmarks" genes for rapid reactivation as cells progress through the cell cycle. However, it is unknown whether such bookmarking factors bind to chromatin similarly in ...
‘Pioneer’ transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prom
Lola-I mediates this function by depleting promoter nucleosomes, similar to the action of pioneer factors at enhancers. These results uncover a level of regulation for promoters that is normally found at enhancers and reveal a mechanism for the de novo establishment of paused Pol II at promoters...