These studies suggest cooperative activation of the bICP0 E promoter by PR and KLF4 correlate with interactions between these pioneer transcription factors.doi:10.1016/j.virusres.2020.198115Laximan Sawant PhDNishani WijesekeraClinton JonesVirus Research...
Pioneer transcription factors direct cell differentiation by deploying new enhancer repertoires through their unique ability to target and initiate remodelling of closed chromatin. The initial steps of their action remain undefined, although pioneers have been shown to interact with nucleosomal target DNA an...
A subset of eukaryotic transcription factors possesses the remarkable ability to reprogram one type of cell into another. The transcription factors that reprogram cell fate are invariably those that are crucial for the initial cell programming in embryonic development. To elicit cell programming or repro...
Pioneer factors are transcription factors with the unique ability to initiate opening of closed chromatin. The stability of cell identity relies on robust mechanisms that maintain the epigenome and chromatin accessibility to transcription factors. Pionee
In addition, cell reprogramming technology has enabled the direct induction of tumor-forming cells from normal somatic cells [15,16] and has evolved to induce stable inhibition of tumor cell proliferation and functional differentiation of tumor cells using a defined set of transcription factors [[17...
Pioneer transcription factors, such as OCT4, are a specific group of transcription factors that can attach to DNA in spite of the nucleosomes, but it's not clear how this is possible. Once pioneer transcription factors attach to DNA they can help other transcription factors to bind alongside ...
Nucleosomes drastically limit transcription factor (TF) occupancy, while pioneer transcription factors (PFs) somehow circumvent this nucleosome barrier. In this study, we compare nucleosome binding of two conserved S. cerevisiae basic helix-loop-helix (bHLH) TFs, Cbf1 and Pho4. A cryo-EM structure...
0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 待分类 系统标签: phapioneertranscriptionpolymerasefactorrecruitment instabilityisacommonpropertywithinnetworks oflow-affinityproteininteractions(22).Itwould allowforstochasticabortionofsitesthatinitiate butfailtocrossagrowth-orcargo-mediatedcheck- point(19,23–...
Pioneer transcription factors: establishing competence for gene expression Transcription factors are adaptor molecules that detect regulatory sequences in the DNA and target the assembly of protein complexes that control gene expr... KS Zaret,JS Carroll - 《Genes & Development》 被引量: 1405发表: ...
densetranscription-factor- bindingplatformswhichareacutelysensitivetopioneermaster regulatorswhoselevelsdefinenotonlyspatialandtemporalfea- turesoflineage-statusbutalsostemness,plasticityintransitional statesanddifferentiation. Hairfolliclestemcellsfuelcyclicalboutsofhairfollicleregeneration andhairgrowthandalsorepairdamaged...