chromatin remodeling, epigenetics, cell differentiation, DNA demethylation, gene transcription, developmentPioneer transcription factors have the unique and important role of unmasking chromatin domains during development to allow the implementation of new cellular programs. Compared to those of other ...
Pioneer transcription factors direct cell differentiation by deploying new enhancer repertoires through their unique ability to target and initiate remodelling of closed chromatin. The initial steps of their action remain undefined, although pioneers have been shown to interact with nucleosomal target DNA an...
Fig. 1. Interplay between pioneer transcription factors (TFs) and epigenetic modifiers: the Polycomb Repressive Complex (PRC), the Nucleosome Remodeling and Deacetylase (NuRD) complex, and the Ten-Eleven Translocation (TET) methylcytosine dioxygenase. Pioneer TFs can recruit specific epigenetic modifiers...
can access their cognate binding motifs in the nucleosome1,4,12,13,14,15,16,17. These pioneer transcription factors play important roles in cell fate reprogramming. For example, the mammalian pioneer transcription factor FoxA reprograms fibroblast to hepatocytes16,18,19,20, while ...
pioneer transcription factors. Pioneer fac- tors function at the earliest stage of tran- scriptional onset to facilitate chromatin opening at cis-regulatory sites, which enables additional factors to bind DNA (1). The founding pioneer factor is mammalianFoxA1, whichassociates with ...
et al. Master transcription factors and mediator establish superenhancers at key cell identity genes. Cell 153, 307–319 (2013). Hsu, Y. C., Li, L. & Fuchs, E. Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Cell 157, 935–949 (2014). Ezhkova, E. et...
While most transcription factors exit the chromatin during mitosis and the genome becomes silent, a subset of factors remains and "bookmarks" genes for rapid reactivation as cells progress through the cell cycle. However, it is unknown whether such bookmarking factors bind to chromatin similarly in ...
matin domains bountiful in cell-type specific transcription factor (TF) binding motifs that enable TFs to bind cooperatively. Their richness in H3K27 acetylation renders super-enhancers mutually exclusive for H3K27me3repression 5,11–13 , while their H3K4me1andMediator complex ...
including CBF genes and transcription factors effective in mitigating the negative effects of freezing, high salinity, and drought on plants, as well as conferring other positive effects on plant phenotype; US2004/0148654 and WO01/36596 where abscisic acid is altered in plants resulting in improved...
including CBF genes and transcription factors effective in mitigating the negative effects of freezing, high salinity, and drought on plants, as well as conferring other positive effects on plant phenotype; US2004/0148654 and WO01/36596 where abscisic acid is altered in plants resulting in improved...