Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting nucleosomal motifs. This pioneer factor (PF) class of chromatin...
In addition, cell reprogramming technology has enabled the direct induction of tumor-forming cells from normal somatic cells [15,16] and has evolved to induce stable inhibition of tumor cell proliferation and functional differentiation of tumor cells using a defined set of transcription factors [[17...
In this article, we review the current state of research on how different viruses (Herpesviruses, Papillomaviruses and Hepatitis B virus) use pioneer factors for their viral replication and persistence in the host, as well as for the development of viral cancer.Neugebauer, Eva...
6c). Both Pol II pausing and chromatin accessibility were not completely abolished, suggesting that other factors, perhaps other Lola isoforms, may help increase the accessibility of the promoters in the absence of Lola-I (Supplementary Fig. 6c). However, the observed changes were not due to a...
祝贺!2023年《Pioneer学术论文期刊》的入围学者名单出炉,131位小学者的论文获得提名并进入最终评选环节。 Pioneer先锋学术特别自豪地公布,共有131位小学者的论文获得2023年《Pioneer学术论文期刊》的提名。自2014年起,本期刊每年出版,向世界展示高中生所取得的惊人学术成就。
The power of pioneer factors to reshape the epigenome also presents an Achilles heel, as their misexpression has major pathological consequences, such as in cancer. In this Review, we discuss the emerging mechanisms of pioneer factor functions and their roles in cell fate specification, cellular ...
Thomas F. Gajewski, MD, PhD, has made inroads in the field of cancer immunotherapy, most notably discovering the connections between the microbiome and clinical outcomes—findings that will enable the creation of microbiota-modulating interventions
Born in Bristol on October 10, 1932, he died in Baltimore on November 9th,... GATA transcription factors are essential in mammalian cell lineage determination and have a critical role in cancer development. In cultured prostate cance... DS Coffey - 《Oncotarget》 被引量: 0发表: 2018年 The...
Structural biology and biophysics, cell biology, stem cell research and therapy, neural and behavioral biology, bioinformatics and computational biology, aging and degenerative diseases, and cancer biology. School of Medicine Microbiology and Vaccine...
selected for publication shortly after the start of thenew year. In the meantime, we congratulate the authors of all the nominated papers, each of whom exemplifies the academic rigor embodied by the Pioneer system. For a complete list of nominated papers and authors, please see the chart below...