Cancer systems biologyEpigeneticsMolecular biologySystems biologyTranscription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have reve
2023年《Pioneer学术论文期刊》的入围学者名单出炉,131位小学者的论文获得提名并进入最终评选环节。 Pioneer先锋学术特别自豪地公布,共有131位小学者的论文获得2023年《Pioneer学术论文期刊》的提名。自2014年起,本期刊每年出版,向世界展示高中生所取得的惊人学术成就。 11年间,来自全球优秀的小学者们经历了层层选拔,入选...
‘Pioneer’ transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prom
Regardless, our findings suggest that it would be useful for those studying other pioneer factors in development, cell reprogramming, and cancer (Zaret and Carroll, 2011) to investigate the role of H1 and its displacement in activating target genes. Although the cooperative binding of TFs can be...
pioneer factors to reshape the epigenome also presents an Achilles heel, as their misexpression has major pathological consequences, such as in cancer. In this Review, we discuss the emerging mechanisms of pioneer factor functions and their roles in cell fate specification, cellular reprogramming and ...
6c). Both Pol II pausing and chromatin accessibility were not completely abolished, suggesting that other factors, perhaps other Lola isoforms, may help increase the accessibility of the promoters in the absence of Lola-I (Supplementary Fig. 6c). However, the observed changes were not due to a...
百度试题 结果1 题目6. She is a pioneer in the development of new cancer treatments.(pioneering) 相关知识点: 试题来源: 解析 答案见上 反馈 收藏
Despite its important role in embryo development, pioneer action is far from being well-understood. Without pioneer factors, our cells wouldn’t be able to diversify to such an extent. As well, pioneer action must occur at the right place and at the right time for a tissue to develop norma...
During her tenure as Director of the Office of Research on Women's Health (ORWH), Dr. Pinn not only pro- moted development of agendas to guide women's health research, but also advocated for attention to the intersec- tion of race/ethnicity and gender, factors impacting wom- en's ...
other governmental entities to cause cancer and birth defect or other reproductive harm. A polarized plug has two blades with one 13) Unplug this apparatus during lightning Wash hands after handling D36-P4_A_En wider than the other. A grounding type storms or when unused for long periods of...