As master regulators of enhancer activation, pioneers are thus crucial for the implementation of correct cell fate decisions in development, and as such, they hold tremendous potential for therapy through cellular reprogramming. The power of pioneer factors to reshape the epigenome also presents an ...
Pioneer factors as master regulators of the epigenome and cell fate. Nat. Rev. Mol. Cell Biol. 23, 449–464 (2022). Article CAS PubMed Google Scholar Soufi, A. et al. Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. Cell 161, 555–568 (...
Pioneer factors as master regulators of the epigenome and cell fate Nat Rev Mol Cell Biol (2022), pp. 1-16, 10.1038/s41580-022-00464-z Google Scholar [42] J.M. Caravaca, G. Donahue, J.S. Becker, X. He, C. Vinson, K.S. Zaret Bookmarking by specific and nonspecific binding of...
2023年《Pioneer学术论文期刊》的入围学者名单出炉,131位小学者的论文获得提名并进入最终评选环节。 Pioneer先锋学术特别自豪地公布,共有131位小学者的论文获得2023年《Pioneer学术论文期刊》的提名。自2014年起,本期刊每年出版,向世界展示高中生所取得的惊人学术成就。 11年间,来自全球优秀的小学者们经历了层层选拔,入选...
These factors, known as pioneer TFs, can help open chromatin, increase DNA accessibility, and support binding of other TFs. Among the TFs shown to bind to closed chromatin, several regulate transitions between cell fates (2). Particularly relevant for inducing pluripotency are Oct4, Sox2, and ...
LETTERdoi:10.1038/nature14289Pioneerfactorsgovernsuper-enhancerdynamicsinstemcellplasticityandlineagechoiceReneC.Adam1,HanseulYang1,Sh..
Indeed, SIM2 DNA binding sites share sequence specificity and overlapping domains of occupancy with master transcription factors such as SOX2, OCT4 (Pou5f1), NANOG or KLF4. The association between SIM2 and these pioneer factors is supported by co-immunoprecipitation of SIM2 with SOX2, OCT4, ...
We look forward to announcing the papers selected for publication shortly after the start of thenew year. In the meantime, we congratulate the authors of all the nominated papers, each of whom exemplifies the academic rigor embodied by the Pioneer system. For a complete list of nominated papers...
The new measures that have been developed, notably impact factors, tell the same story, as do the number of submissions and the rejection rates. The importance for peace research to have a journal with that very name and with the recognition for quality cannot be exaggerated. There are three...
what to consider take these factors into account to determine the best fit for a soon-to-be high school student. cole claybourn april 23, 2024 metro areas with top-ranked high schools these metro areas, scattered throughout the u.s., boast the best public high schools in the nation. a....