PI3K/Akt/mTORC信号通路参与调控恶性肿瘤细胞的增殖、存活、转录、翻译和代谢等过程,其机制如下: PI3Ks可被跨膜受体比如酪氨酸激酶受体、G-蛋白偶联受体、人类表皮生长因子受体2和胰岛素样生长因子-1受体等激活,也可以被Ras蛋白激活;激活后...
Fourneaux B, Chaire V, Lucchesi C, Karanian M, Pineau R, Laroche-Clary A, Italiano A. Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications. Oncotarget. 2017; 8:7878-7890. ...
百度试题 题目NTRK基因参与的信号通路有:() A.RAS/RAF/MEK/ERKB.PI3K/AKT/mTORC.PKC或PLCγD.A+B+C相关知识点: 试题来源: 解析 D 反馈 收藏
PI3K/Akt/mTORC信号通路参与调控恶性肿瘤细胞的增殖、存活、转录、翻译和代谢等过程,其机制如下: PI3Ks可被跨膜受体比如酪氨酸激酶受体、G-蛋白偶联受体、人类表皮生长因子受体2和胰岛素样生长因子-1受体等激活,也可以被Ras蛋白激活;激活后引起自磷酸化,促使生成第二信使PIP3;PIP3与细胞内含有PH结构域的信号蛋白Akt...
Han, L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways, J. Biol, Chem. 286 (2011) 23,667-23,678.Ryu JM, Han HJ (2011) l -threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs,...
Factors predisposing to development of hyperglycaemia in phase 1 studies involving PI3K, mTOR, AKT and mTORC1 and mTORC2 inhibitorsWong, MKhan, K HRihawi, KBodla, SAmin, BilalShah, Krunal JMorganstein, DKaye, Stanley BBanerji, UdaiMolife, L Rhoda...