Full size image Table 1 Frequency of PI3K pathway alterations in cancer. Full size table Survival signals are different from apoptosis resistance and protect cancer cells from death. Therefore, the signaling involved in apoptosis resistance and increased survival are the main regulators of MDR in chem...
Altogether, our data illustrate different PKC isoforms regulating PI3K pathway at multiple levels, suggesting a mechanism to control signal flows through PI3K for normal cell activities. Although further investigation is required for full understanding of the regulatory mechanism, we propose that complex ...
B. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 4, 988–1004 (2005). Article CAS PubMed Google Scholar Rommel, C., Camps, M. & Ji, H. PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat. Rev. ...
Given that the PI3K/AKT pathway has manifested its compelling influence on multiple cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in various human cancers. We state the abnormalities of PI3K/AKT pathway in different cancers, which are closely related with tumor...
Full size table Expression of upstream components of the PI3K survival pathway (Akt, GSK-3β) were surveyed. The steady-state level of Akt mRNA (Table 1) and phosphorylated protein (Table 2) were increased in the muscles of MSTN-null mice. Differential expression of the GSK-3β was confirm...
agents by selectively targeting the pathway in cancerous but not healthy cells, thus overcoming a key limitation of currently available medicines that target the PI3Kα pathway. This approach could potentially offer better disease control through deeper pathway inhibition, as well as improved ...
Particularly in myocytes, LA, palmitic acid and AA increase the intracellular Ca2 + signal through a pathway inhibited by 100 μM La3 + [30], also known to block Cx HCs. Mammalian myocytes express Cxs 40, 43 and 45 [28], which also form functional HCs [44], [45]. Since LA also ...
3. Chinese medicine monomers against cervical cancer by regulating the PI3K/Akt signaling pathway 4. Conclusion Funding Ethics approval and consent to participate CRediT authorship contribution statement Conflict of interest statement Acknowledgments Data Availability ReferencesShow full outline Cited by (16)...
Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and ...
Full size image BEFV triggers autophagy via activation of the Src/JNK/AP1 pathway Having demonstrated that BEFV-induced autophagy, at least in part, occurs via the PI3K/Akt/NF-κB pathway in the early to middle stages of infection. As shown in Figures 4A and 6A, an increase in the phos...