On Trk--the TrkB signal transduction pathway is an increasingly important target in cancer biology. Clin Cancer Res. 2009;15(19):5962–7. Article CAS PubMed PubMed Central Google Scholar Yoshii A, Constantine-Paton M. Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and ...
This process occurs after nerve growth factor (NGF) binds to its tyrosine kinase receptor Trk, leading to neuronal differentiation by the Ras-mitogen activated protein kinase (MAPK) signaling pathway [5]. MAPK family members act as integration points for multiple biochemical signals, and they are ...