Erlich et al., " STI1 Promotes Glioma Proliferation Through MAPK and PI3K Pathways, " GLIA 55, 1690-1698 (2007).Erlich RB, Kahn SA, Lima FR, Muras AG, Martins RA, Linden R, Chiarini LB, Martins VR, Moura Neto V. STI1 promotes glioma prolifera- tion through MAPK and PI3K pathways....
例如, MAPK 、 PI3K 网络、NFκB 和 JAK-STAT 通路的介质之间的相互作用已有充分记录 [7]。 图 哺乳动物 MAPK 信号级联一系列蛋白包含 4 种主要 MAPK 级联,包括 ERK 、 p38 、 JNK 和 ERK5。生长因子启动的信号转导与 ERK 通路相关,而 JNK 、 p38 和 ERK5 通路是由细胞因子、环境应激(包括渗透...
PI3K和MAPK信号通路调节细胞增殖 OPEN ORIGINAL ARTICLE Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation P Daniel 1,G Filiz 1,DV Brown 1,F Hollande 1,M Gonzales 1,2,G D’Abaco 3,N Papalexis 4,WA Phillips 5,6,J Malaterre 6,...
Involvement of MAPK and PI3K pathways in neutrophil migration was investigated by pretreating neutrophils with inhibitors of p38 MAPK, JNK, MEK1/2, and PI3K. The capacity of a p38 MAPK inhibitor at decreasing neutrophil chemotaxis toward the airways was also evaluated in vivo.ResultsBALF from ...
【关键词】MAPKs；PI3K；胃癌 【中图分类号】R735.2 【文献标识码】B 【文章编号】1003-5028（2015）8-0840-02 To Discuss the Role of MAPKs and PI3K Pathways in Gastric Cancer and Their Significance Wang Feng,Wu Zhi-Feng,Huang Xiu-Qing,Lin Li-Lin,Weng Jian-Wu, Liu Biao,Chen Xiu-Ji...
现将 PI3K/Akt和 Ras /MAPK通路及其相互作用综述如下。 【关键词】 丝裂原,激活蛋 白激酶类 ;基因,ras; 磷脂酰肌醇类 ;蛋 白质丝氨酸苏氨酸激 酶,信号转导 Ras/MAPK通路和 PI3K/丝苏氨酸蛋 白激酶 对肿瘤治疗预后的影响 。 (Akt)通路是膜受体信号向细胞 内转导的重要途径, 磷脂酰肌 醇一3一激 酶 (...
GLUT4的移位需要PI3K/Akt通路的参与和IR介导的CAP的磷酸化和形成CAP:Cbl:CrkII复合体。胰岛素信号通路也会影响细胞生长和有丝分裂,主要是通过Akt级联进行,也会有Ras/MAPK通路的参与。另外,胰岛素信号通路可以通过中断CREB/CBP/Torc2的结合抑制肝脏中的糖异生。胰岛素信号通路还可以通过激活SREBP-1C,USF1和LXR来促进...
In our previous study, we have shown that adding BDNF to the cells could activate the tyrosine kinase, and further PI3K and MAPK pathways only in the TrkB-expressing cells (TET−), not the non-TrkB-expressing cells (TET+) [11]. By using this system, we studied the role of BDNF/...
Ras/MAPK与PI3K/Akt信号转导通路 及其相互作用 国际检验医学杂志2006年3月第27卷第3期IntJLabMed.March2006,Vo1.27,No.3 Ras/MAPK与PI3K/Akt信号转导通路及 其相互作用 袁向飞综述陆敏审校 【摘要1Ras/MAPK通路和PI3K/Akt通路是膜受体信号向细胞内转导的重要途径, 它们调节 着细胞凋亡,生长以及一些重要基因的表...
31, 32 Crucially, T98G and U118 differ in PTEN status (T98G PTEN+ and U118 PTEN−), which may account for the differential CREB-mediated regulation of cell cycle factors via interaction with the MAPK and PI3K pathways.33, 34 Treatment of T98G cells with siCREB resulted in an almost ...