The PI3K pathway in human disease. FRUMAN D A,CHIU H,HOPKIN B D,et al. Cell . 2017Fruman D, Chiu H, Hopkins B, Bagrodia S, Cantley L, and Abraham R (2017) The PI3K pathway in human disease. Cell 170:605-635Fruman, David A.,Chiu,etc.The PI3K Pathway in Human Disease[J]....
The PI3K Pathway in Human Disease 作者:Fruman David A; Chiu Honyin; Hopkins Benjamin D; Bagrodia Shubha; Cantley Lewis C; Abraham Robert T 来源:Cell, 2017, 170(4): 605-635. DOI:10.1016/j.cell.2017.07.029 摘要 Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes...
human cancer. Driven by this discovery, medicinal chemistry ef- forts have yielded a large toolbox of PI3K pathway inhibitors with varied selectivity profiles, many of which are being tested in clin- ical trials for cancer (Table S1). Along the way, we have learned ...
Leading EdgeReviewThe PI3K Pathway in Human DiseaseDavid A. Fruman, 1, * Honyin Chiu, 1 Benjamin D. Hopkins, 2 Shubha Bagrodia, 3 Lewis C. Cantley, 2 and Robert T. Abraham 31 Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92697-3900, ...
The PI3K pathway in human disease Cell, 170 (4) (2017), pp. 605-635 View PDFView articleView in ScopusGoogle Scholar 2. M. Whitman, C.P. Downes, M. Keeler, et al. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate Nature, 332 (6165)...
Janku, F., Yap, T. A. & Meric-Bernstam, F. Targeting the PI3K pathway in cancer: are we making headway?Nat. Rev. Clin. Oncol.15, 273–291 (2018). Google Scholar Fruman, D. A. et al. The PI3K pathway in human disease.170, 605–635 (2017). ...
The PI3K-mTOR signaling pathway has been studied extensively in human disease. This pathway has key functions in regulating cell growth, survival and metabolism, and is aberrantly activated in a number of malignant or non-malignant diseases. Components of this pathway have become attractive drug ...
3. We summarize the recent research progress regard- ing the PI3K/AKT/mTOR signalling pathway in com- mon human diseases (neurodegenerative diseases and tumours). 4. We aimed to provide useful suggestions for addi- tional research on the mechanism underlying the biological regulation of this ...
T. (2017). The PI3K pathway in human disease. Cell, 170(4), 605–635. 18. Mossmann, D., Park, S., & Hall, M. N. (2018). mTOR signal- ling and cellular metabolism are mutual determinants in cancer. Nature Reviews Cancer, 18(12), 744–757. https://doi.org/10....
Placenta-derived mesenchymal stem cells (PL-MSCs) have therapeutic potential in various clinical contexts due to their regenerative and immunomodulatory properties. However, with increasing age or extensive in vitro culture, their viability and function