作者:Bonate, Peter L. 出版社:Springer Verlag 出版年:2005-10 页数:400 定价:$ 111.87 装帧:HRD ISBN:9780387271972 豆瓣评分 目前无人评价 评价: 推荐 内容简介· ··· A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a spec...
Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects 动力学模型石杉碱甲中老年人群体乙酰胆碱酯酶抑制剂阿尔茨海默氏病药代动力学仿真瞄准:我们的初步的结果显示出那 huperzine A,一个 acetylcholinesterase 禁止者过去常对待 Alzheimers 在中国的疾病(广告) 病人,在老,年轻的...
Pharmacokinetic modeling and simulation of etodolac following single oral administration in dogs.EtodolacpharmacokineticscompartmentalMonte Carlo simulationdog1. Etodolac is a nonsteroidal anti-inflammatory drug with selective cyclooxigenase-2 inhibition to treat pain and inflammation associated with osteoarthritis...
Pharmacokinetic/pharmacodynamics (PK/PD) modeling, an integral component of the drug development process, is a mathematical technique for predicting the effect and efficacy of drug dosing over time. Broadly speaking, pharmacokinetic models describe how the body reacts to a drug in terms of absorption...
Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteersdotinuradPK/PD modelURAT1uric aciduricosuric agentThis study aimed to investigate the pharmacokinetic and pharmacodynamic (PK/PD) profiles of dotinurad, a novel uricosuric agent, and to ...
ModelingandsimulationAmenamevir is a novel drug that targets the viral helicase鈥損rimase complex. While dose-dependent efficacy had been observed in non-clinical studies, no clear dose dependence has been observed in humans. We therefore developed a pharmacokinetic/pharmacodynamic (PK/PD) model to...
Modeling and simulation studies predict that 325 mg/m(2) LEP-ETU q3w provides acceptable neutropenic events relative to those observed at 175 mg/m(2) Taxol q3w. A 275 mg/m(2) dose may offer an improved therapeutic index. 展开 关键词:...
Zhao P, Zhang L, Grillo JA, Liu Q, Bullock JM, Moon YJ, Song P, Brar SS, Madabushi R, Wu TC, Booth BP, Rahman NA, Reynolds KS, Gil Berglund E, Lesko LJ, Huang SM (2011) Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review. ...
To demonstrate using pharmacokinetic (PK) modeling and simulation, that the PK that the PK parameters for drug exposure with galantamine parameters for drug exposure with galantamine immediate-release (IR) tablet and galantamine extended-release (ER) capsule are comparable in patients with Alzheimer's...
Modeling, Simulation, and Model-Based Drug Development—Part 2: Introduction to Pharmacokinetic Modeling Methods DR Mould1 and RN Upton1,2 Population pharmacokinetic models are used to describe the time course of drug exposure in patients and to investigate sources of variability in patient exposure....