Pharmacokinetics Pharmacokineticsis the subdiscipline of pharmacology concerned with the way the body affects the drug. This includes studies of the absorption, metabolism and excretion of the chemical agent. Such work is vital for determining whether the drug reaches the desired site of action and rem...
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The decision to proceed to the next dose cohort was made by both investigators and sponsor according to the dose-escalation termination criteria described in the protocol. The dose-escalation termination criteria were determined by AEs. Dose escalation should be terminated when any of the following c...
Undoubtedly, the best way to reduce the risk of developing smoking-related chronic disease and increase life expectancy is to stop smoking cigarettes altogether7,8,9; however, quitting smoking is not so easy. One study has estimated that it may take up to 30 attempts before a smoker quits su...
This impressive turnaround was made possible by easy availability of appropriate tools, for example, Caco-2 cells, recombinant cytochrome P450 (CYP) isozymes, pooled human liver microsomes, and importantly the integration of DMPK into drug discovery at an early stage such that DMPK properties can ...
The SwissADME web tool presented here is freely accessible athttp://www.swissadme.chand meant for user-friendly submission and easy analysis of the results, also for nonexpert in CADD. Compared to the state-of-the art of free web-based tools for ADME and pharmacokinetics (e.g. pk-CSM14...
With minimal PBPK models, it is easy to incorporate additional tissue compartments, such as tumor and skin as the site of absorption, and additional kinetics, such as target antigen binding into the specific tissue compartments. 4.2. Use of PBPK Model to Mechanistically Describe and Predict mAb ...
With minimal PBPK models, it is easy to incorporate additional tissue compartments, such as tumor and skin as the site of absorption, and additional kinetics, such as target antigen binding into the specific tissue compartments. 4.2. Use of PBPK Model to Mechanistically Describe and Predict mAb ...