PHARMACOKINETICSTYPE 2 diabetesPHARMACODYNAMICSCOMMERCIAL product testingBackground: Type 2 diabetes mellitus (T2DM) and its associated complications and comorbidities often require polypharmacotherapy, resulting in a high pill burden and reduced therapy adherence, thereby increasing the risk ...
Research based on quantitative analysis, pharmacokinetics and metabolomics was conducted to explore the effects of salt-processing on Psoraleae Fructus (PF). Quantitative analysis showed that the contents of bioactive components were higher in salt-processed Psoraleae Fructus (SPF) extract than in PF ...
The results can provide scientific reference for the study of pharmacokinetics, metabolite prediction, pharmacodynamic material basis and mechanism of action about Coptidis Rhizome Dispensing Granule. Key words: Coptidis Rhizome Dispensing Granule metabolism in vivo UHPLC-Q-TOF/MS...
Efficacious material basis of Chinese formulation is one of the key scientific study aspects in the modernization of Chinese Material Media (CMM). On the basis of the previous work, this paper raised a new concept of "indicated pharmacokinetics of traditional Chinese medicine (TCM)" and analyzed ...
Further Study of Indicated Pharmacokinetics of Traditional Chinese Medicine中药复方指征药代动力学的深入思考 Efficacious material basis of Chinese formulation is one of the key scientific study aspects in the modernization of Chinese Material Media (CMM). On the b... Liu Jianxun,Lin Li,Zhang Ying,...
In conclusion, the present study provided a method for simultaneous determination of luteolin, apigenin, chrysoeriol and diosmetin in rat plasma, which had been successfully utilized in pharmacokinetics study of FCE in rats, and also could be applied in future clinical study of FCE. The pharmacokine...
suggesting that etomidate has no high variability from the perspective of pharmacokinetics. The intra-CV of Cmax(21.17%) in the study was lower than the intra-CV of Cmax(32.8%) in pilot tiral 2. The reason for this difference may be related to the smaller number of subjects in the pilot...
Topiramate is a new antiepileptic drug (AED) that has been approved worldwide (in more than 80 countries) for the treatment of various kinds of epilepsy. I... M Bialer,DR Doose,B Murthy,... - 《Clinical Pharmacokinetics》 被引量: 256发表: 2004年 A Comparative Study of the Effect of ...
OBJECTIVE To develop the formulation of silymarin self-microemulsifying capsules and study its pharmacokinetics in rats.METHODS The formulation was screened by investigating solubility of silymarin in different mediums and constructing pseudo-ternary phase diagram.The dissolution profile and the morphology of...
However, the three-exponential model analysis well fitted the plasma concentration of both compounds and was comparable to parameters calculated by non-compartmental model; accordingly, two compartment model was considered as suitable for rat pharmacokinetics34. Our results also show that all observed ...