Research based on quantitative analysis, pharmacokinetics and metabolomics was conducted to explore the effects of salt-processing on Psoraleae Fructus (PF). Quantitative analysis showed that the contents of bioactive components were higher in salt-processed Psoraleae Fructus (SPF) extract than in PF ...
PHARMACOKINETICSTYPE 2 diabetesPHARMACODYNAMICSCOMMERCIAL product testingBackground: Type 2 diabetes mellitus (T2DM) and its associated complications and comorbidities often require polypharmacotherapy, resulting in a high pill burden and reduced therapy adherence, thereby increasing the risk ...
Efficacious material basis of Chinese formulation is one of the key scientific study aspects in the modernization of Chinese Material Media (CMM). On the basis of the previous work, this paper raised a new concept of "indicated pharmacokinetics of traditional Chinese medicine (TCM)" and analyzed ...
In conclusion, the present study provided a method for simultaneous determination of luteolin, apigenin, chrysoeriol and diosmetin in rat plasma, which had been successfully utilized in pharmacokinetics study of FCE in rats, and also could be applied in future clinical study of FCE. The pharmacokine...
suggesting that etomidate has no high variability from the perspective of pharmacokinetics. The intra-CV of Cmax(21.17%) in the study was lower than the intra-CV of Cmax(32.8%) in pilot tiral 2. The reason for this difference may be related to the smaller number of subjects in the pilot...
Topiramate is a new antiepileptic drug (AED) that has been approved worldwide (in more than 80 countries) for the treatment of various kinds of epilepsy. I... M Bialer,DR Doose,B Murthy,... - 《Clinical Pharmacokinetics》 被引量: 256发表: 2004年 A Comparative Study of the Effect of ...
Disclosed are a traditional Chinese medicine composition which has the effect of improving cognition, a preparation method therefor, and a traditional Chin... S Zou,Z Zhang,X Li,... 被引量: 0发表: 2021年 Herb-herb interaction in traditional Chinese medicine:a review of pharmacokinetics-based ...
OBJECTIVE To develop the formulation of silymarin self-microemulsifying capsules and study its pharmacokinetics in rats.METHODS The formulation was screened by investigating solubility of silymarin in different mediums and constructing pseudo-ternary phase diagram.The dissolution profile and the morphology of...
A possible explanation may be the different pharmacokinetics of these drugs. In other words, since the more complete or sustained ACE inhibition seen with the longer-acting agents may be detrimental33, DPP-4Is are suggested to inhibit ACEs for a longer-acting duration and also be more likely ...
However, the three-exponential model analysis well fitted the plasma concentration of both compounds and was comparable to parameters calculated by non-compartmental model; accordingly, two compartment model was considered as suitable for rat pharmacokinetics34. Our results also show that all observed ...