A physiologically based pharmacokinetic model was developed to describe the tissue distribution and elimination of pentazocine in the anesthetized rat. The model incorporates renal and hepatic (metabolic and biliary) elimination, GI secretion, GI reabsorption and tissue-to-blood partition coefficients. The...
physiologically based pharmacokinetic modelThis report is the third in a series of studies that aimed to compile physiological parameters related to develop physiologically based pharmacokinetic (PBPK) models for drugs and environmental chemicals in food锕憆oducing animals including swine and cattle (Part ...
Physiological-pharmacokinetic-model网络生理药代动力学模型;生理药物动力学模型网络释义 1. 生理药代动力学模型 ... physiological barrier 生理屏障 physiological pharmacokinetic model 生理药代动力学模型 physostigmine 毒扁豆碱 ... jpk.ezu.cn:8080|基于4个网页 2. 生理药物动力学模型 ...(二)生理药物动力学模...
Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. Tissue-to-plasma water partition coefficients (Kpu's) form an integral part of whole body physiologically based pharmacokinetic (WBPBPK) models. This resea... T Rodgers,D Leahy,M Rowland...
Physiologically based pharmacokinetic (PBPK) models are growing in popularity due to human food safety concerns and for estimating drug residue distribution and estimating withdrawal intervals for veterinary products originating from livestock species. This paper focuses on the physiological and anatomical data...
W. Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A. Toxicol. Appl. Pharmacol. 289, 442–456 (2015). Article CAS PubMed Google Scholar Sarigiannis, D. A. et al. Integrated exposure and risk characterization of bisphenol-A in Europe....
Reig-Lopez, J., Merino-Sanjuan, M., Mangas-Sanjuan, V., & Prado-Velasco, M. (2020).A Multilevel Object- Oriented Modelling Methodology for Physiologically-Based Pharmacokinetics (PBPK): Evaluation with a Semi-Mechanistic Pharmacokinetic Model. Computer Methods and Programs in Biomedicine, 105322...
The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model for amoxicillin for non-pregnant, pregnant and postpartum populations by compiling a database incorporating reported changes in the anatomy and physiology throughout the postpartum period. A systematic ...
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Using physiologically-based pharmacokinetic (PBPK) modeling, occupational, personal, and environmental benzene exposure scenarios are simulated for adult m... EA Brown,ML Shelley,JW Fisher - 《Risk Analysis》 被引量: 90发表: 1998年 Effect of potassium on morphological and physiological paramters in ...