Antibody-mediated immunity plays an important role in the host defense system, being the first non-physical barrier formed to prevent pathogens from entering the body. In accordance with this definition, questions regarding the possible influence of phage treatment on the antibody response in humans ...
Characterization of Salmonella Isolates from Various Geographical Regions of the Caucasus and Their Susceptibility to Bacteriophages No less than 61.5% of the isolates were shown to be multidrug-resistant. A new antimicrobial treatment strategy is urgently needed. Phage therapy, the ... K Makalatia,E...
Integrating global and local genomic surveillance into phage therapy cocktail design offers a middle ground between personalized and product-based treatment options. Lorenz Leitner Shawna McCallin News & Views28 Oct 2024 Nature Microbiology Volume: 9, P: 2799-2800 Phage genome engineering with retron...
Phage Therapy as an Alternative Treatment in the Fight Against AMR: Real-World Problems and Possible Futures In the last few years, a renewal of interest blossom on bacteriophages and other alternative therapies to antibiotics has been evident in the antimicrobial arena. Unfortunately, the dawn of ...
Vitalis shall communicate with you regarding treatment procedure. Frequently Asked Questions WHAT ARE PHAGES? Phages are naturally occurring viruses that attack, infect and feed on bacteria. They are the most abundant organisms in nature. They are everywhere – in food, water, air, and even in ou...
We performed ten replicates for each treatment and randomly selected five replicates that did not contain any phage-resistant mutants for subsequent imaging and quantitative analysis. Thus, we excluded the evolution of phage resistance during the time-course of the experiment, which typically occurred ...
In early twentieth century, Felix ded’Herelle and Frederick Twort independently discovered the concept of ‘phage therapy’ and used in the treatment of bacterial infections (d'Herelle1961). The distinctive ability of phages to specifically target living bacterial hosts was used not only for therap...
Phages could activate both cellular and humoral immunity, which is another goal of an effective vaccine design. Also, phages act as an effective adjuvant, along with the antigens, and induce a robust immune response. Phage-based vaccines can also be administered orally because of their stability...
Viruses that infect bacteria (bacteriophages; also known as phages) were discovered 100 years ago. Since then, phage research has transformed fundamental and translational biosciences. For example, phages were crucial in establishing the central dogma of molecular biology — information is sequentially pa...
The use of phage-encoded lytic protein-endolysin instead of phages for MDR bacterial treatment [28]. Endolysins are a group of viral hydrolytic enzymes responsible for degrading the bacterial cell wall peptidoglycan layer (PG) during the replication cycle, thereby releasing viral progeny. They ...