Targeted Delivery of Bacteriophages to the Gastrointestinal Tract and Their Controlled Release Danish J.Malik, inMicrobiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications, 2019 Gastrointestinal Bacterial Infections The use ofphage therapyis a particularly promising alternative to broad...
for example, phage-mediated delivery during acute infection can be considered as the better methods of therapy. However, for strains of a given bacteria that has difference on phage susceptibility, an alternative phage-delivery method or vehicle...
Syndrome Infectious Complications of Trophic Ulcers Purulent Dermatitis Wounds PAEDIATRICS Bacterial Conjunctivitis Bepharitis ENT Conditions Gastrointestinal Diseases HEALTHCARE ASSOCIATED INFECTIONS Healthcare associated infections, also known as nosocomial infections, are acquired from hospitals or healthcare ...
Phage therapy, long overshadowed by chemical antibiotics, is garnering renewed interest in Western medicine. This stems from the rise in frequency of multi-drug-resistant bacterial infections in humans. There also have been recent case reports of phage therapy demonstrating clinical utility in resolving...
Phage therapyWhat is phage therapy? Phage therapy is an exciting antimicrobial strategy that has the potential to transform the care of a wide range of bacterial infections, including DFI. Bacteriophage (phage) are viruses that infect and kill bacteria in a species-, sometimes even strain-, speci...
For the first time, scientists have designed a phage combination therapy that can precisely target and suppress gut bacteria associated with inflammatory bowel diseases (IBD). Presented on August 4 in the journalCell, the work showcases the possibility of using phages for treating diseases associated...
Escherichia coli is a commensal bacterial species in the human gastrointestinal tract; however, it could be pathogenic and cause severe infections in intra and extra-intestinal sites. Uropathogenic E. coli accounts for 80–90% of urinary tract infections
in human metabolism, immune modulation, and protection against pathogens.2,4In addition, imbalances in their community contribute to human diseases or conditions such as Inflammatory Bowel Disease (IBD), allergies, obesity, and more.2,3Similarly, changes in phage composition have been observed in ...
Phage Therapy - Part A Safia Samir, in Progress in Molecular Biology and Translational Science, 2023 2.3 Novel Staphylococcal phages with unique morphology and broad host range 2.3.1 Phage JD219 It is a temperate phage with unstable lysogeny. The phage rapidly replicates and lyses the host cell...
in the gastrointestinal tract, enzymatic degradation, and short serum half-life, resulting in low bioavailability and protein structure damage [197]. The topical application of endolysins involves using ointments, creams, and gels for direct delivery to infection sites. However, the stratum corneum ...