RNase MCPIP1 regulates hepatic peroxisome proliferator-activated receptor gamma via TXNIP/PGC-1alpha pathwayMCPIP1Peroxisome proliferator-activated receptor gammaTXNIPObesityFatty liverMonocyte chemoattractant protein-1-induced protein-1 (MCPIP1) acts as an endonuclease that degrades selected mRNAs, viral ...
PGC1Alpha PathwayDescription:PGC1Alpha (Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1-Alpha) is a tissue-specific transcriptional coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for cellular energy metabolism and overall energy ...
Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway. Food Funct. 12(18), 8800–8811 (2021) Article CAS PubMed Google Scholar Y. Liu et al. PGC-1alpha protects against oxidized low-density lipoprotein and luteinizing hormone-induced granulosa cells injury ...
In this study, we explored the distribution and role of the mitochondrial antioxidants peroxiredoxin-3 and thioredoxin-2 as well as their regulator peroxisome proliferator-activated receptor gamma coactivator1-alpha (PGC-1α) in MS pathogenesis. Immunohistochemical analysis of a large cohort of MS ...
Highlights ► The intestinal hormone, FGF15/19, inhibits postprandial hepatic gluconeogenesis ► FGF15/19 is induced after insulin to regulate postprandial hepatic metabolism ► FGF15/19 suppresses gluconeogenesis by inhibiting the CREB-PGC-1α pathwayPrevious...
Mechanistically, we found that the KML001-induced telomeric DDR activated p53 signaling, which in turn repressed the expression of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1伪) and nuclear respiratory factor 1 (NRF-1), leading to T cell mitochondrial dysfunction. ...
Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1alpha pathway 来自 万方 喜欢 0 阅读量: 254 作者:M Ding,F Na,D Tang,J Feng,Z Li 摘要: Myocardial contractile dysfunction is associated with an increase in mitochondrial fission in patients with diabetes. ...
Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1alpha pathway Myocardial contractile dysfunction is associated with an increase in mitochondrial fission in patients with diabetes. However, whether mitochondrial fissio... M Ding,F Na,D Tang,... - 《Journal ...
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007; 450: 736–740. 26. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator...
Taken together, these results suggest that high dosage of taurine administration during the early postnatal period can significantly improve the cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1α pathway. Therefore, taurine has therapeutic potential for prenatal ...