PGC1Alpha PathwayDescription:PGC1Alpha (Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1-Alpha) is a tissue-specific transcriptional coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for cellular energy metabolism and overall energy ...
Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-alpha/sirtuin 1/PGC-1alpha pathway. Br J Pharmacol. 2016;173:1095- 1109.Guang‐zhong Liu, Ting‐ting Hou, Yue Yuan, Peng‐zhou Hang, Jing‐jing Zhao, Li Sun, et al. Fenofibrate inhibits atrial metabolic ...
Taken together, these results suggest that high dosage of taurine administration during the early postnatal period can significantly improve the cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1α pathway. Therefore, taurine has therapeutic potential for prenatal ...
Mechanistically, we found that the KML001-induced telomeric DDR activated p53 signaling, which in turn repressed the expression of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1伪) and nuclear respiratory factor 1 (NRF-1), leading to T cell mitochondrial dysfunction. ...
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007; 450: 736–740. 26. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator...
PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res. 17, 363-373.YanZhang, YiBa, ChangLiu, GuoxunSun, LiDing, SongyuanGao, JihuiHao, ZhentaoYu, JunfengZhang, KeZen, ZhongshengTong, YangXiang, Chen-YuZhang. (2007) PGC-1α ...
Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1alpha pathway 来自 万方 喜欢 0 阅读量: 254 作者:M Ding,F Na,D Tang,J Feng,Z Li 摘要: Myocardial contractile dysfunction is associated with an increase in mitochondrial fission in patients with diabetes. ...
(NAM). Additionally, immunofluorescence, western blotting, and reverse transcription polymerase chain reaction were used to evaluate changes in the expression of Bcl-2 and Bax in the mouse hippocampus, and SIRT1/PGC-1α signaling pathway proteins were detected. Moreover, the oxidative stress markers...
A very tangible consequence of this relationship emerges from our examination of this pathway during exercise under physiological and disease conditions. Physical exercise requires energy sources in the form of ATP mostly derived from mitochondria. Physical exercise is an established inducer of PGC-1α ...
The protein bands were visualized using the AlphaImager© imaging system and bands quantified with Image J (NIH). Numbers below immunoblots represent densitometry relative to actin. Tissue NO• measurement Electron paramagnetic resonance spectrometry (EPR) was used to assess vascular NO• synthesis...