PGC1Alpha PathwayDescription:PGC1Alpha (Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1-Alpha) is a tissue-specific transcriptional coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for cellular energy metabolism and overall energy ...
Mechanistically, we found that the KML001-induced telomeric DDR activated p53 signaling, which in turn repressed the expression of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1伪) and nuclear respiratory factor 1 (NRF-1), leading to T cell mitochondrial dysfunction. ...
The SIRT1/PGC-1α signaling pathway is closely related to changes in cellular antioxidants, apoptosis, and mitochondrial function [41,42,43]. In our in vivo experiments, hematoxylin–eosin staining was applied to the CA1, CA3, and DG subregions of the mice hippocampus to observe the pyramidal...
PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res. 17, 363-373.YanZhang, YiBa, ChangLiu, GuoxunSun, LiDing, SongyuanGao, JihuiHao, ZhentaoYu, JunfengZhang, KeZen, ZhongshengTong, YangXiang, Chen-YuZhang. (2007) PGC-1α ...
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007; 450: 736–740. 26. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator...
Taken together, these results suggest that high dosage of taurine administration during the early postnatal period can significantly improve the cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1α pathway. Therefore, taurine has therapeutic potential for prenatal ...
Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1alpha pathway 来自 万方 喜欢 0 阅读量: 254 作者:M Ding,F Na,D Tang,J Feng,Z Li 摘要: Myocardial contractile dysfunction is associated with an increase in mitochondrial fission in patients with diabetes. ...
PGC1alpha Suppresses Prostate Cancer Cell Invasion through ERRalpha Transcriptional Control. Cancer Res. 2019;79:6153–65. Article CAS PubMed Google Scholar Tolvanen TA. Current Advances in CETSA. Front Mol Biosci. 2022;9:866764. Article CAS PubMed PubMed Central Google Scholar Yun S-H, ...
Stein, R. A. et al. Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.Cancer Res.68, 8805–8812 (2008). ArticleCASPubMedPubMed CentralGoogle Scholar Gaillard, S. et al. Receptor-selective coactivators as tools to define the biology of spec...
Highlights ► The intestinal hormone, FGF15/19, inhibits postprandial hepatic gluconeogenesis ► FGF15/19 is induced after insulin to regulate postprandial hepatic metabolism ► FGF15/19 suppresses gluconeogenesis by inhibiting the CREB-PGC-1α pathwayPrevious...