1. Villena, J.A. (2015). New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond.FEBS Journal282, 647–672. 2. Chambers, J.M., and Wingert, R.A. (2020). PGC-1...
PGC一1o【在耐力运动训练过程中增加骨骼肌收缩活动,能促骨骼肌适应,而且PGC-1O/ .基因 表达在自适过程中起到中枢作用。PGC一1 是一个转录辅激活因子,它可以诱导肌肉线粒体生 物合成,是运动诱导的表型适应和底物if-1用的主要调节剂,诱导快肌纤维向慢肌纤维转换, ...
2009 . SUMOylation attenuates the function of PGC-1alpha . J. Biol. Chem. 284 : 26184 – 26193 .Rytinki MM, Palvimo JJ. SUMOylation attenuates the function of PGC-1alpha. J Biol Chem 2009;284:26184-26193Rytinki M. M. and Palvimo J. J. ( 2009 ) SUMOylation attenuates the ...
Peroxisome proliferator activated receptor gamma, coactivator 1α (PGC-1α) is a unique stress sensor that largely acts to promote adaptive responses. Therefore, we sought to define the role of endothelial PGC-1α in vascular function using mice with endothelial specific loss of function (PGC-1...
PGC-1α(全称:Peroxisome proliferator-activated receptor γ coactivator 1-alpha)是一种转录共激活因子,是关键的调节能量代谢和适应性修复过程的蛋白质。它在许多生物学过程中发挥重要作用,包括线粒体生物发生、有氧呼吸、糖原合成和肌肉适应性。PGC-1α的分子量约为91 kDa。 PGC-1α在人类和小鼠中均有表达,并...
(PPARs)and PPAR’/coactivator-1alpha(PGC-lot)work togethertoregulatethe energy metabolism.Mitochondrial cardiomyopathy is a diseasecharacterized by myocardial damage andabnormal energy metabolic that results from abnormalities in mitochondfiaquantity,structure and function in cardiac myocytes.However’there is...
The Role of PGC1alpha in Cancer Metabolism and its Therapeutic Implications. Tan, Z.; Luo, X.; Xiao, L.; Tang, M.; Bode, A. M.; Dong, Z.; Cao, Y. The Role of PGC1alpha in Cancer Metabolism and its Therapeutic Implications. Molecular cancer therapeutics 2016, 15, 774-82. [49...
PGC 1alpha null mice J Cell 2004 119 1 121 135 7 Walter I Seebacher F Molecular mechanisms underlying the development of endothermy in birds Gallus gallus a new role of PGC 1 J Am J Physiol Regul Integr Comp Physiol 2007 293 6 2315 2322 8 Cassard Doulcier AM Gelly C Fox N et al ...
regulation of ovarian function will be discovered.This review briefly summarized the function of PGC-1αin ovary and research progress,which may provide new reference for the diagnosis and treatment of some ovarian diseases.【Keywords】Peroxisome proliferator-activated receptor gamma coactivator1alpha;Ovary...
pgc-1α分子量pgc-1α分子量 PGC-1α(Peroxisome proliferator-activated receptor gamma coactivator-1alpha)是一种转录辅激活因子,它在调节能量代谢、线粒体生物合成和氧化应激反应中发挥重要作用。其分子量约为91.6 kDa。 PGC-1α是由PPARGC1A基因编码的蛋白质。PPARGC1A基因是在基因组上位于4p15.1-p15.3位置,...