PGC-1alpha functions as a co-suppressor of XBP1s to regulate glucose metabolism. Mol. Metab. 2018, 7, 119-131. [CrossRef] [PubMed]Lee J, Salazar Hernandez MA, Auen T, et al. PGC-1alpha functions as a co- suppressor of XBP1s to regulate glucose metabolism. Mol Metab. 2018;7:119...
1. Villena, J.A. (2015). New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond.FEBS Journal282, 647–672. 2. Chambers, J.M., and Wingert, R.A. (2020). PGC-1...
The Role of PGC1alpha in Cancer Metabolism and its Therapeutic Implications. Tan, Z.; Luo, X.; Xiao, L.; Tang, M.; Bode, A. M.; Dong, Z.; Cao, Y. The Role of PGC1alpha in Cancer Metabolism and its Therapeutic Implications. Molecular cancer therapeutics 2016, 15, 774-82. [49...
Peroxisome proliferator activated receptor gamma, coactivator 1α (PGC-1α) is a unique stress sensor that largely acts to promote adaptive responses. Therefore, we sought to define the role of endothelial PGC-1α in vascular function using mice with endothelial specific loss of function (PGC-1...
This review focuses on the role of PGC-1alpha in glucose metabolism and considers how PGC-1alpha links cellular glucose metabolism, insulin sensitivity and mitochondrial function, and why defects in PGC-1alpha expression and regulation may contribute to the pathophysiology of type 2 diabetes in ...
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. |核心内容: 过氧化物酶体-增殖物激活受体辅激活剂(PGC)-1 α 转录复合物控制线粒体氧化功能,以维持能量稳态对营养和激素信号的反应。能量和营养途径中的一个重要组成部分是哺乳动物雷帕霉素靶蛋白(mTOR) ,这是一...
PGC-1 Dictionary, Encyclopedia and Thesaurus - The Free Dictionary13,773,652,265visits served TheFreeDictionary Google ? Keyboard Word / Article Starts with Ends with Text EnglishEspañolDeutschFrançaisItalianoالعربية中文简体PolskiPortuguêsNederlandsNorskΕλληνικήРусс...
and reducing PGC-1α levels in obese and diabetic mouse liver restores XBP1s protein induction.ConclusionsOur findings reveal a novel function of PGC-1α as a suppressor of XBP1s function, suggesting that hepatic PGC-1α promotes gluconeogenesis through multiple pathways as a co-activator for HNF...
30, 31 The focus has been on developmental and juvenile mice, and PGC-1α function in the sensitive adult inner retina has not been addressed previously. We investigated the role of PGC-1α in regulating the susceptibility of RGCs to metabolic and oxidative damage in wild-type (WT) and ...
regulation of ovarian function will be discovered.This review briefly summarized the function of PGC-1αin ovary and research progress,which may provide new reference for the diagnosis and treatment of some ovarian diseases.【Keywords】Peroxisome proliferator-activated receptor gamma coactivator1alpha;Ovary...