R. (2015). PPARγ and PGC-1α as therapeutic targets in Parkinson’s. Neurochemical Research, 40 , 308–316. CentralCorona JC & Duchen MR 2015 PPARgamma and PGC-1alpha as therapeutic targets in Parkinson's. Neurochemical Research 40 308-316. (doi:10.1007/s11064-014-1377-0)...
Recent studies suggest that activation of PPARγ-peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α) stimulates mitochondrial biogenesis and induces beneficial effects on mitochondrial function in animal models of neurodegenerative disorders including PD, AD, HD (Aguiar Jr, ...
心脏中PPARs的活性受过氧化物酶体增殖物激活受体γ共激活因子1(peroxisome proliferator-activated receptorγcoactivator-1,PGC-1)调节,PGC-1α负责线粒体的生物发生和代谢。PGC-1α是心脏中高表达的基因。PGC-1α的过表达显着增加了核和线粒体相关基因的表达,从而将代谢能底物从葡萄糖变为脂肪酸。 PPARα通过激...
MATERIALS AND METHODS: Adenovirus-mediated gene transfer was performed to overexpress PGC-1alpha in HepG2 human hepatoma cells. Small interference RNA (siRNA) was used to silence the expression of E-cadherin and PPARgamma. Cell motility was assessed by transwell cell migration analysis. Measurements...
PPAR-γ及其共激活因子PGC-1α在神经退行性变和神经炎症的细胞分化和线粒体生物发生中发挥重要作用[19] [20]。有研究报道PPARα激动剂(GW7647)不仅能抑制β淀粉样蛋白(Aβ)的生成,也能降低阿尔茨海默症细胞模型中sAPPβ的表达、BACE-1活性[21]。同时也有学者发现磷脂酰肌醇3-激酶(PI3-K)在PPAR信号通路中起...
is the main constituent of senile plaques and is largely involved in neuronal death and neuroinflammation. peroxisome proliferator-activated receptor gamma coactivator-1 alpha (pgc-1α) is one of the main transcriptional coactivator and has been related to many fields such as energy metabolism, ...
PGC 1alpha(PPARgammaCoacticator 1α)是PPAR辅助活化因子,通过PPARα或γ调控编码与脂质代谢、脂质运输有关功能蛋白的基因表达,影响体内脂代谢平衡[5]。白藜芦醇能激活PGC 1alpha和组蛋白脱乙酰酶,增强脂肪和肌肉组织线粒体的生成和功能,促进能量消耗,抑制肥胖并显著延长寿命[6]。
factor21.PPARdeltainducesgenesforLCFAoxidationduringfastingandenduranceexerciseinskeletalmuscle.PPARdeltaalsoregulatesglucosemetabolismandmitochondrialbiogenesisbyinducingFOXO1andPGC1alpha.PPARgammacaninducesthepathwaystostoreLCFAsastriglyceridesinadipocytes.Adiponectin,anotherimportanttargetofPPARgammamaymaintaininsulinsensitivity...
目的 从粪便代谢组学和过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptor alpha,PPARα),过氧化物酶体增殖子活化受体γ共激活因子(peroxisome proliferator-activated receptor gamma coactivator,PGC)-1α探讨逍遥丸对非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)大鼠的治疗作用.方法 24只雄...
PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes Cell Metab., 4 (2006), pp. 407-414 Google Scholar Seale et al., 2008 P. Seale, B. Bjork, W. Yang, S. Kajimura, S. Chin, S. Kuang, A...