Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1αpathway. Ding M,Feng N,Tang D,Feng J,Li Z,Jia M,Liu Z,Gu X,Wang Y,Fu F,Pei J. Journal of Pineal Resarch . 2018Ding, M.; Feng, N.; Tang, D.; Feng, J.; Li, Z.; Jia, M.; Liu,...
Tools Pathway Builder Protein Hydroplotter Clone Easy Peptide Finder Easy siRNA Institutional License Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License. To set up a license, please contact: info@proteinlounge.comCopyright...
These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 directly. Inhibition of mitochondrial fission may be a potential target for delaying ...
Tornatore L, Thotakura AK, Bennett J, Moretti M, Franzoso G: The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation. Trends Cell Biol 2012, 22: 557–566. 10.1016/j.tcb.2012.08.001 Article CAS PubMed Google Scholar Storer PD, Xu J, Chavis J, Drew PD: Per...
Faculty Opinions recommendation of Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. 来自 Semantic Scholar 喜欢 0 阅读量: 1 作者:P Griffin,N Kumar DOI: 10.3410/f.4113957.3893055 年份: 2010 ...
Moreover, the inhibition of the p38 MAPK pathway by SB203580 efficiently abolished icariin-stimulated cardiomyocyte differentiation and resulted in the capture of the upregulation of PGC-1alpha, PPARalpha, and NRF-1. CONCLUSION: Taken together, icariin promoted the expression of PGC-1alpha, PPAR...
关键词:过氧化物酶体增殖物激活受体γ 辅激活因子1α;油酸; 小鼠肝癌细 胞;P38 丝裂原活化蛋白激酶 2 万方数据 The role of Oleic Acid on the expression of PGC-1α in mouse hepa 1-6 cells and the signal pathway Abstact Objective To investigate the effect of Oleic Acid(OA) on the expression...
Formononetin Ameliorates Cognitive Disorder via PGC-1 alpha Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice 来自 掌桥科研 喜欢 0 阅读量: 40 作者: Fu, XinxinQin, TingtingYu, JiayuJiao, JieMa, ZhanqiangFu, QiangDeng, XueyangMa, Shiping 摘要: Background: Alzheimer's ...
This novel regulatory link, as well as the marked reduction in patient survival time associated with increased glutamine pathway gene expression, suggests that targeting may have therapeutic potential in the treatment of + . 展开 被引量: 61 ...
A very tangible consequence of this relationship emerges from our examination of this pathway during exercise under physiological and disease conditions. Physical exercise requires energy sources in the form of ATP mostly derived from mitochondria. Physical exercise is an established inducer of PGC-1α ...