Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1alpha pathway-mediated mechanism. Int Int J Obes (Lond) 2016;40:1841-9.Zhang X, Zhang QX, Wang X, Zhang L, Qu W, Bao B, Liu CA, Liu J. Dietary luteolin activates browning and thermogenesis in mice ...
在能量压力下,AMPK也激活过氧化物酶体增殖物活化受体γ(PPARγ)共激活因子1α(PGC1α),通过与PPARγ或雌激素相关受体(ERRs)相互作用激活线粒体生物合成的基因。虚线箭头表示潜在的间接调节关系。 AMPK与线粒体 越来越多的证据表明:AMPK特异性调控线粒体生物过程来维持稳态(图3),包括控制线粒体的生物合成来调控...
关键词:利格列汀;糖尿病肾脏疾病;线粒体生物合成;AMPK/PGC-1α/TFAM 信号通路 Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway WAN Lu1, QIAN Yuchi1, 3, NI Wenjing1, 2, LU Yuxin1, LI Wei1, PAN Yan1, CHEN Wei...
AMPK调控PGC1α可能包括几种间接机制,如p38MAPK127,HDAC524,128和SIRT1129,所以,AMPK与PGC1α的作用是一系列机制的共同作用结果(图3)。 此外,在有些情况下,AMPK促进转录因子EB(TFEB,下文讨论)的激活,并且TFEB已被证明直接结合激活编码PGC1α基因PPARGC1A的启动子131...
The core role of AMPK/PGC-1α signaling pathway in cancer metabolism The AMPK, a type of enzyme called a serine/threonine kinase, has remained similar in various species through evolution. It has a significant function in controlling cellular energy and redox homeostasis and affects all aspects ...
Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway... Author: Haijuan Liu, et. al. Year: 2025 Page 1 of 518 限制使用 除非CST 的合法授书代表以书面形式书行明确同意,否书以下条款适用于 CST、其关书方或分书商提供的...
PGC-1α and PPARα abundance in HFD-fed rats and PA-exposed HepG2 cells. HFD-feeding resulted in a decrease in the hepatic PPARα and PGC-1α mRNA expression, and the protein expression of p-AMPK, PGC-1α, and PPARα exhibited significant changes (Fig.6A, B). DHM administration ...
线粒体自噬是分裂所必需的,受损的线粒体被自噬所降解。在能量压力下,AMPK也激活过氧化物酶体增殖物活化受体γ(PPARγ)共激活因子1α(PGC1α),通过与PPARγ或雌激素相关受体(ERRs)相互作用激活线粒体生物合成的基因。虚线箭头表示潜在的间接调节关系。
We found that the protein and mRNA expression levels of AMPK, PGC1-α, FNDC5, and irisin were significantly lower in the DHEA + HFD group compared to the control group, which indicated that the expression of irisin pathway-related molecules in the gastrocnemius muscle were downregulated. ...
Sestrin2 silencing exacerbates cerebral ischemia/reperfusion injury by decreasing mi- tochondrial biogenesis through the AMPK/PGC-1alpha pathway in rats. Sci Rep 2016; 6: 30272.L. Li, L. Xiao, Y. Hou et al., "Sestrin2 silencing exacerbates cerebral ischemia/reperfusion injury by decreasing ...