Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1 alphaacute kidney injurydiabetic nephropathyfibrosismitochondriaproteinuriaThe kidney has extraordinary metabolic demands to sustain the active transport of solutes that is critical to renal filtration and clearance. ...
We tested the hypothesis that repeated activation of AMP-activated protein kinase (AMPK) induces mitochondrial and glucose membrane transporter mRNA/protein expression via a peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha)-dependent mechanism. Whole body PGC-1alpha-knockou...
(aa 566-710). PGC-1 alpha activity is regulated by phosphorylation. AMPK is known to phosphorylate Thr178 and Ser539, promoting cotranscriptional activity. Conversely, Akt-mediated phosphorylation at Ser571 is reported to downregulate PGC-1 alpha activity. This latter effect is achieved by an ...
modificationsPhosphorylation by AMPK in skeletal muscle increases activation of its own promoter (By similarity). Phosphorylated by CLK2. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions. ...
目录号 GTX135859 GTX135859 WB Image Rat tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with PGC1 alpha antibody (GTX135859) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. ...
4 Activated AMPK could monitor mitochondrial function and cellular energy status.5 At the same time, it regulates the activity of the silent information regulator 1 (SIRT1) and increases the intracellular NAD+ which can activate the NAD+-dependent SIRT1 to exert biological effects. Activated AMPK...
CONCLUSIONS/SIGNIFICANCE: PGC-1alpha down-regulation is likely to contribute to the blunted antioxidant response observed in cells from FRDA patients. This response can be restored by AMPK and PPARgamma agonists, suggesting a potential therapeutic approach for FRDA. 展开 ...
Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant e
C1q/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1α/AMPK-Mediated Antioxidant Enzyme Induction Oxidized low-density lipoprotein (ox-LDL) accumulation is one of the critical determinants in endothelial dysfunction in many cardiovascular diseases such ... H Sun,X ...
Faculty Opinions recommendation of Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. 来自 Semantic Scholar 喜欢 0 阅读量: 1 作者:P Griffin,N Kumar DOI: 10.3410/f.4113957.3893055 年份: 2010 ...