Therefore, our present data showed that, by the AMPK-PGC-1伪-Sirt3 pathway, ZL006 protects spinal cord neurons against ischemia through reducing mitochondrial oxidative stress to prevent apoptosis.doi:10.1016/j.neuint.2017.04.005Shu-Guang Liu...
有趣的是,有报道显示几种与氧化代谢相关的基因在活化时需要PGC1α的表达17,而过度持续激活AMPKγ3亚基可以增加PGC1α的表达111。在细胞水平,PGC1α的两个位点Thr177和Ser538被AMPK磷酸化17。确定它们是否是AMPK体内的靶点需要更多的研究。AMPK调控PGC1α可能包括几种间接机制,如p38MAPK127,HDAC524,128和SIRT1129...
AMPK调控PGC1α可能包括几种间接机制,如p38MAPK127,HDAC524,128和SIRT1129,所以,AMPK与PGC1α的作用是一系列机制的共同作用结果(图3)。 此外,在有些情况下,AMPK促进转录因子EB(TFEB,下文讨论)的激活,并且TFEB已被证明直接结合激活编码PGC1α基因PPARGC1A的启动子131。除PGC1α,AMPK已经被证实在KRAS驱动的结肠癌...
AMPK调控PGC1α可能包括几种间接机制,如p38MAPK127,HDAC524,128和SIRT1129,所以,AMPK与PGC1α的作用是一系列机制的共同作用结果(图3)。 此外,在有些情况下,AMPK促进转录因子EB(TFEB,下文讨论)的激活,并且TFEB已被证明直接结合激活编码PGC1α基因PPARGC1A的启动子131...
没食子酸(gallic acid,15)来源于山茱萸科植物山茱萸的干燥果实,具有抗菌、抗病毒和抗肿瘤作用。Doan等[36]研究显示,没食子酸通过激活AMPK/Sirt1/PPARγ共激活因子-1α(PGC-1α)通路,改善饮食诱导肥胖小鼠的胰岛素敏感性和稳定血糖。 姜酚存在于姜的根茎中,有多种异构...
已有文 献报道,利格列汀可以通过激活 AMPK/SIRT1/PGC-1α 通路达到减轻醋酸诱导的大鼠结肠炎的效果[11].利格 列汀通过激活 AMPK 通路,进而缓解内毒素诱导的肾 损伤[12].而利格列汀在 DKD 中能否通过激活 AMPK/ PGC-1α/TFAM 通路,促进线粒体生物合成,缓解线粒体 功能紊乱,进而改善肾脏损伤,还需进一步验证....
SIRT3 was induced by PGC-1β together with ERRα during RANKL-induced osteoclast differentia- tion, and it may function as a negative mediator for osteoclastogenesis through stabilization of AMPK protein. Thus, our data suggest that SIRT3 plays an important role as a molecular brake on ...
In addition, ZL006 stimulated mitochondrial enzyme activities and SOD2 deacetylation in a Sirt3-dependent manner. The results of western blot analysis showed that ZL006 increased the activation of AMPK-PGC-1α-Sirt3 pathway, and the beneficial effects of ZL006 was partially abolished by AMPK ...
??3. 线粒体AMPK通路修复?? 针灸提升AMPK及其磷酸化水平(P<0.01),激活SIRT1/PGC-1α轴(P<0.01),改善线粒体生物合成。其中,PGC-1α mRNA表达量增加1.37倍(P<0.01),提示针灸可能通过增强线粒体功能缓解IR。 创新与局限 研究首次证实针灸对T2DM两大核心通路的协同调控作用,且效果与格列美脲相当(OGTT-AUC改善更...
系统标签: neurochem ampk pgc ischemia oxidative neurons Thepromiseofepigenetictherapy:reprogrammingthecancerepigenomeAndrewDKellyandJean-PierreJIssaEpigeneticsreferstoheritablemoleculardeterminantsofphenotypeindependentofDNAsequence.EpigeneticfeaturesincludeDNAmethylation,histonemodifications,non-codingRNAs,andchromatinstruct...