Hypoxia had variable effects on expression of SIRT1, AMPK, SIRT3, and SIRT3 activity depending on the sex. The capacity of the fetal heart to respond to hypoxia differs depending on the gestational age of exposure and sex of the fetus. Further, the effects of late-onset hypoxia on fetal ...
Molecular Genetics and Genomics - The discovery and interpretation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protein in mitochondrial biogenesis,... 展开 关键词: PGC-1 alpha Mitochondrial biogenesis Skeletal muscle Adipose tissue Mitochondria ACTIVATED PROTEIN-KINASE COACTI...
(aa 566-710). PGC-1 alpha activity is regulated by phosphorylation. AMPK is known to phosphorylate Thr178 and Ser539, promoting cotranscriptional activity. Conversely, Akt-mediated phosphorylation at Ser571 is reported to downregulate PGC-1 alpha activity. This latter effect is achieved by an ...
Founded in 2006, Affinity Biosciences is committed to providing the best quality primary antibody|secondary antibody|peptide|reagent kit|inhibitor|antibody customization|antibody query for the world, the phosphorylated antibody has become the name card o
Anti-phospho-AMPK alpha 1(Thr172)/Cy3 荧光素(Cy3)标记的磷酸化腺苷单磷酸活化蛋白激酶α1抗体 Anti-phospho-Kidins220(Ser919)/PE PE标记的磷酸化220kDa蛋白激酶D相互作用蛋白抗体 Anti-Phospho-CENP-A (Ser7)/FITC 荧光素(FITC)标记的磷酸化着丝粒蛋白A Anti-Phospho-Cyclin D1 (Thr286)/PE PE标记...
markedly increased the contents of ATP and NAD+, decreased ADP and AMP contents and the ratio of AMP/ATP, reduced the level of ROS and MDA, enhanced SOD activity, evidently increased the levels of AMPK, SIRT1 and PGC-1 alpha mRNA, up-regulated the expressions of AMPK, pAMPK, SIRT1, ...
Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant e
This review mainly focuses on interconnecting role of PGC-1 alpha and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition.Thirupathi, Anandde Souza, Claudio TeodoroUniv Extremo Catarinense Lab Exercise Biochem &Journal of ...
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. C Canto,J Auwerx. Current Opinion in Lipidology . 2009Canto,C. and Auwerx,J. (2009) PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr. Opin. Lipidol., 20...
(AMPK)α2, anti-phosphatidylinositol 3 (PI3)-kinase (Upstate, Lake Placid, NY, USA); anti-Akt phosphos473, anti-Akt phosphothr308, anti-Akt substrate of 160 kDa (AS160; Cell Signalling, Danvers, MA, USA); anti-Akt substrate of 160 kDa (AS160) phosphothr642 (Medicorp, Montreal, QC...