PD-1/PD-L1 简介 PD-1(Programmed cell death protein 1,程序性死亡受体1),又称CD279(分化簇 279),是人类体内由 PDCD1 基因编码的蛋白质。PD-1是T细胞和B细胞上的细胞表面受体,其通过抑制T细胞炎症活动,可以下调免疫系统并促进自我耐受以调节免疫系统对人体细胞的反应。这可以预防自身免疫性疾病,但也可以阻止...
An analysis of the relationship of clinical activity to baseline EGFR status, PD-L1 expression and prior treatment history in patients with non-small cell ... L Horn,R Herbst,D Spigel,... 被引量: 46发表: 2013年 High co-expression of PD-L1 and HIF-1α correlates with tumour necrosis ...
Results After testing, the positive expression rate of P53 was 42.50%, while PDL 1 was 37.50%. There were no significant differences in P53 and PDL 1 protein expression in sex, age, Hans typing, differentiation degree, or clinical stage (P>0.05), but significant differences in efficacy, ...
Programmed Cell Death Protein 1 (PD-1),一种在激活的 T 细胞上表达的受体,与其配体 PD-L1 和 PD-L2 结合,负向调节免疫反应。 PD-1 配体存在于大多数癌症中,PD-1:PD-L1/2 相互作用会抑制 T 细胞活性,并使癌细胞逃避免疫监视。 PD1/PDL1信号转导通路是肿瘤免疫抑制的重要组成部分,可以抑制T淋巴细胞的...
[2]Tsao, MING SOUND, et al. IASLC atlas of PD-L1 immunohistochemistry testing in lung cancer. Aurora, CO: International Association for the Study of Lung Cancer (2017). [3]2018 ESMO handbook of immune-oncology. [4]Davis, Andrew ...
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer...
(FAT1-L) AML cells. We also found that CQ weakened CD8+T cell infiltration in FAT1-L AML cells. Further research revealed that CQ upregulated PD-L1 protein levels by decreasing its autophagic degradation and that the PD-L1 inhibitor atezolizumab reversed the decrease in CD8+T cell ...
Programmed Cell Death Protein 1(PD-1) ,一种在激活的 T 细胞上表达的受体,与其 配体 PD-L1 和 PD-L2 结合,负向调节免疫反应。 PD-1 配体存在于大多数癌症中,PD- 1:PD-L1/2 相互作用会抑制 T 细胞活性,并使癌细胞逃避免疫监视。 PD1/PDL1 信号转导通 路是肿瘤免疫抑制的重要组成部分,可以抑制 T ...
Figure 13C is an image showing Th1 cell SHP1/2 protein expression by western blot analysis with SHP1 or SHP2 siRNA treatment. Figure 13D is an image demonstrating that untreated Th1 cells, Th1 cells with PD1 knockdown, and Th1 cells treated with SHP1/2 SiRNA (n=5 donors) were ...
Spindle Apparatus Coiled-Coil Protein 1 (SPDL1) is a relatively recently identified coiled-coil domain containing protein and an important determinant of DNA fidelity by ensuring faithful mitosis. Hence, SPDL1 is suspected to underlie genomic (in-)stability in human cancers, yet its exact roles ...