thatcorrelatedwithPD-L1expressionontumor cells(TC)and/ortumor-infiltratingimmunecells (IC);(Spigeletal.,ASCO2015;Hornetal.,ASCO 2015;Liuetal.,ASCO2015) SpiraAIetal,JClinOncol33,2015(suppl;abstr8010) TC350%PDL1+ IC310%PDL1+ r e i k c i r T n e v E Nivolumab:SquamousPopulation Nivoluma...
第二军医大学硕士学位论文PD-1/PD-L1途径在脓毒症T淋巴细胞和单核细胞中的作用及机制研究姓名:***学位级别:硕士专业:生物化学与分子生物学指导教师:**龙;焦炳华20100501PD-1/PD-L1途径在脓毒症T淋巴细胞和单核细胞中的作用及机制研究摘要脓毒症(sepsis)是一种创伤、感染等引起机体过激的炎症反应从而对人体产生...
MP32-13PDL1 EXPRESSION ON TUMOR INFILTRATING IMMUNE CELLS AND SOMATIC GENE ALTERATIONS ASSOCIATED WITH RESPONSE TO IMMUNOTHERAPY IN PATIENTS WITH ADVANCED BLADDER CANCERdoi:10.1097/JU.0000000000003265.13John HeardPeris CastanedaEric LoMichael Ahdoot
pdl1在肝癌组织中的表达及临床意义研究-expression and clinical significance of pdl 1 in hepatocellular carcinoma PD-L1在肝癌组织中的表达及临床意义研究中文摘要PD-L1在肝癌组织中的表达及临床意义研究中文摘要目的:应用免疫组织化学方法研究PD-L1在肝癌组织、癌旁组织及正常组织中的表达差异,探讨其与肝癌临床病理...
sinb7一hlexpression.JImmuneI,2005,175(2):1145—1152.【28】DayCL,KaufmannDE,Kiepielaetal.PD-IexpressionHIV—specificTcel1sisassociatedwithT-cellexhaustiondiseaseprogression.Naturo,2006,433(7109):350-354.[29】TrautmannL,JanbazianL,Chomontetal.UpregulationPD一1expressionHIV—specificCD8+Tcells1cadsro...
A,BUSP44 expression in different HCC cell lines and normal liver cell line L02 examined by western blot and qRT-PCR.C–FThe outcomes of USP44 knockdown and overexpression were examined by western blot and qRT-PCR in HCC cells.G–NThe Colony formation assay and the CCK-8 assay were used ...
1.本文披露了使用与人ox40、人pd1或人pdl1结合的抗体或其抗原结合片段的组合治疗癌症的方法。 背景技术: 2.ox40(也称为act35、cd134或tnfrsf4)是一种大约50kd的i型跨膜糖蛋白并且是肿瘤坏死因子受体超家族(tnfrsf)的成员(croft,2010;gough和weinberg,2009)。成熟人ox40由249个氨基酸(aa)残基组成,具有37个...
PD-L1 expression in patient tissues was analyzed using RK-10-Cy5 and compared to expression in MDA-MB-231 cells and a negative control of normal blood (Fig.5). The MFI of the MDA-MB-231 cells was 9,448, while the whole blood gave an MFI of −123 (S9). Squamous cell carcinoma ...
The SPDL1 expression was positively correlated with the immune infiltration of CD8+ T-cells and cancer-associated fibroblasts (CAFs) in most of the tumor types. Nuclear division, organelle fission and chromosome segregation were involved in the functional mechanisms of SPDL1. Conclusions These ...
infection, stably transduced cells were sorted based on expression of mCherry. HLA-A2+MDA-MB-468 cells were generated similar to the above described Luc2 transduction but instead using the pMP71-HLA-0201-His vector (Addgene, 108214). Sorting was based on binding of the anti-HLA-A2 antibody...