恶性肿瘤发病机制及转化研究教育部重点实验室、贵州大学医学院等团队合作的研究成果Preclinical imaging evaluation of a bispecific antibody targeting hPD1/CTLA4 using humanized mice(人源化小鼠对hPD1/ CTLA4双特异性抗体的临床前影像学评价)在学术期刊《Biomedicine & Pharmacotherapy》发表。
Given this fact, PD1/CTLA4 double-humanized mice models were established in both BALB/c (BALB/c-hPD1/hCTLA4) and C57BL/6 (B6-hPD1/hCTLA4) background, which by replacing the mouse extracellular domain of CTLA4 and PD1 with human segments while retaining mouse intact intracellular part, ...
参考文献 Du X, Liu M, Su J,et al. Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice[J]. Cell research, 2018, 28(4): 433-447.
Δ42PD1+Vδ2 cells in vivo, they were adoptively transferred into autologous humanized mice, resulting in small intestinal inflammatory damage, probably due to the interaction of Δ42PD1 with its cognate receptor Toll-like receptor 4 (TLR4). In addition, blockade of Δ42PD1 or TLR4 ...
All animal experiments were approved by the Animal Care Committee of Kunming Medical University. BALB/c nude male mice (5–6 weeks old) and Humanized NOD/LtSz-scid/IL2Rγnull(HuNSG) male mice (5–6 weeks old) were obtained to Shanghai Model Organisms Center, Inc. (Shanghai, China). ...
Preclinical experiments in humanized animal tumor models demonstrated antitumor activities of QL1706, with evidence of a functional dual blockade of both the PD-1 and CTLA-4 pathways (Additional file 1: Fig. S4). The detailed information is presented in the Additional file 1. Fig. 1 Generation...
Atezolizumab is a humanized IgG1monoclonal antibody to PDL1, and was the first PD1/PDL1 inhibitor approved by the FDA for treatment of advanced UC, based on results from the IMvigor 210 clinical study.Citation19,Citation32The approved indications for atezolizumab in advanced UC are similar to pe...
"Coexpression of Tim-3 and Pd-1 Identifies a Cd8+ T-Cell Exhaustion Phenotype in Mice with Disseminated Acute Myelogenous Leukemia." Blood 117 17 (2011): 4501-10. 4. Herndler-Brandstetter, Dietmar, et al. "Humanized mouse model supports development, function, and tissue residency of human ...
To investigate the role of Δ42PD1 + Vδ2 cells in vivo, they were adoptively transferred into autologous humanized mice, resulting in small intestinal inflammatory damage, probably due to the interaction of Δ42PD1 with its cognate receptor Toll-like receptor 4 (TLR4). In addition, blockade ...
HuNSG mice with a humanized immune system. All the results described above indicated that exosomal circUSP7 secreted by NSCLC cells mediates resistance to anti-PD1 therapy by inducing CD8+T cell exhaustion, which may provide a previously undescribed therapeutic target for the treatment of NSCLC ...