近日，同济医学院兰培祥、陈刚和陈知水共同在期刊《Journal for Immuno Therapy of Cancer》发表题为“LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy”的文章，通过使用荷瘤小鼠模型，我们
CD8⁺ T cellsPD1/PDL1 axistumor microenvironmentimmune checkpoint inhibitorsPD1/PDL1 axis controls CD8 T cell exhaustion in gastric cancer.Tumor microenvironment modulates immune checkpoint signaling pathwaysNoncoding RNAs influence immune evasion via PD1 and PDL1 expressionNovel combination therapies ...
相反，乐伐替尼单独处理扩大pDC、IFNγ+CD8+T和GzmB+CD8+T细胞亚群，乐伐替尼和抗PD-1药物联合用药...
近日,同济医学院兰培祥、陈刚和陈知水共同在期刊《Journal for Immuno Therapy of Cancer》发表题为“LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy”的文章,通过使用荷瘤小鼠模...
在肿瘤中,PD-1阻断导致PD-1+CD8+T细胞功能增强以及PD-1+Treg细胞介导的免疫抑制增强。治疗开始时,PD-1+CD8 T细胞与PD-1+Treg的比率可能会指导最终免疫反应的结果。因此,在检查这些疗法对患者总体预后的影响时,必须考虑PD-1抑制剂对这些对立细胞群(效应细胞与调节细胞)功能的集体影...
During aging, CD8+ T cells acquire an exhausted phenotype, including increased expression of inhibitory receptors, such as programmed cell death 1 (PD1), a decline in effector function and elevated expression of inflammatory factors3,4,5,6,7. PD1 reduces T cell receptor activity via SHP2-...
Conclusion The tumor-infiltrating CD8+T-lymphocytes that express PD-1 do not have a normal function, which may be the reason that TIL can not kill tumor cells effectively. [Key words] Tumor;T lymphocyte;PD1 Corresponding author: Zhu Bo, E-mail: oncology_bozhu@ 肿瘤现已成为发达国家的首要...
“Trajectory and Functional Analysis of PD-1highCD4+CD8+T Cells in Hepatocellular Carcinoma by Single-Cell Cytometry and Transcriptome Sequencing”的研究成果,采用质谱流式细胞仪、单细胞测序等研究方法,发现CD4/CD8 双阳性 T (DPT) 细胞的存在,并表征了 DPT 细胞的分子特征,DPT细胞在 HCC中的独特分布和...
参考文献[1] Chen DS, Mellman I: Oncology meets immunology: the cancer-immunity cycle. Immunity 2013, 39(1):1-10.[2] Maimela NR, Liu S, Zhang Y: Fatesof CD8+ T cells in Tumor Microenvironment. Comput Struct Biotechnol J 2019, 17:1-13.[3] Pardoll D: Cancer and the Immune System...
2.1 肿瘤局部浸润性CD8+T细胞分离与鉴定 为确定肿瘤局部是否存在浸润性淋巴细胞,肿瘤局部分离得单个核细胞后染CD8+表型,发现确存在肿瘤浸润性CD8+T淋巴细胞(图1A),为进一步明确CD8+T细胞亚群,复染PD1,发现存在一CD8+T细胞亚群高表达衰竭性表型PD1(图1B)。