www.nature.com/scientificreports OPEN received: 08 June 2016 accepted: 24 October 2016 Published: 14 November 2016 PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients Hye Ryun Kim1, Sang-Jun Ha2, Min Hee ...
PD-L1 positivity in immune cells did not correlate with stage (p=0.7), grade (p=0.1) or OS (p=0.8). Conclusions: PD-L1 expression is variable in non-ccRCC and depends on histology and tumor vs. immune cells scoring. Only PD-L1 positivity in tumors cells was associated with aggressive...
We have demonstrated in this study that anlotinib can inhibit PD-L1 expression on VECs so as to break through the “immune tolerance barrier”, promote CD8+T cells infiltration, improve the balance of CD8/FoxP3. This work provides new insights into the effects of antiangiogenic therapy on tumo...
陈哲生教授:Colorectal cancer (CRC) ranks among the top three most prevalent cancers globally. Despite the approval of immune checkpoint inhibitors like PD-1 inhibitors for CRC treatment, over 85% of patients with proficient...
of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer[J]．Cancer Immunol Immunother, 2020, 69(12): 2477-2499.DOI: 10.1007/s00262-020-02628-2.LiuC, YaoZ, WangJ, et al.Macrophage-derived CCL5 facilitates immune ...
PD-L1 expression on tumors or immune cells can independently attenuate antitumor T cell immunity. PD-1+ T cells in the tumor are impaired due to interactions with PD-L1 expressed on either tumor cells (Juneja et al., 2017) or other tumor-infiltrating immune cells (e.g., myeloid cells ...
KowanetzM, ZouW, GettingerSN, et al.Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)[J]. Proc Natl Acad Sci U S A, 2018, 115(43): E10119-E10...
19. Shin J, Chung J-H, Kim SH, et al. Effect of platinum-based chemotherapy on PD-L1 expression on tumor cells in non-small cell lung cancer. Cancer Res Treat. 2019;51(3):1086-1097. 20. Rimm DL, Han G, Taube JM, et al. A prospective, multi-institutional, pathologist-based asse...
[2].Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515(7528):568-571. doi:10.1038/nature13954 [3].Oh SA, Wu DC, Cheung J, et al. PD-L1 expression by dendritic cells is a key regulator of T-cell ...
使用SP142抗体检测时,除了TC结果判读标准与22C3、28-8相同外,还需检测免疫细胞(immune cell, IC)染色情况,这也是目前使用该抗体检测NSCLC的特殊之处。IC计数范围包括肿瘤内和/或紧邻的肿瘤周围连续间质中,除外坏死区域;IC群体包括淋巴细胞...