None of the endocrine tissues demonstrated PD-L1 positivity higher than 1% in the relevant cells. Conclusion While our results do not suggest a role of PD-L1 expression in the pathogenesis of endocrine irAEs, they may serve as a basis for future studies further investigating the mechanisms of ...
Aim: In this study, we evaluated patterns of programmed cell death ligand 1 (PD-L1) expression in normal endocrine tissues to determine whether increased expression may explain the predilection of endocrinopathies in patients treated with PD-1 inhibitors. Methods: Immunohistochemical (IHC) analysis ...
Soluble Programmed Cell Death Ligand-1 (sPD-L1) Levels in Various Cancer Types and Normal Populations Background: To date, PD-L1 expression in tumor tissue, assessed by immunohistochemical stain, is clinically applicable as a predictive companion biomarker ... SH Lee,HJ Park,JY Moon,... - 《...
However, few studies have been performed in EC. The purpose of the present study was to assess the expression of PD-1, PD-L1 and PD-L2 in 35 human normal endometrial tissue samples and 75 human EC tissue samples using immunohistochemical staining. It was found that 61.3% of ECs were ...
[1]. It is composed of 273 amino acid residues and comprised of 7 exons which consist of IgV-like domain, IgC-like domain, transmembrane domain, and cytoplasmic (intracellular) domain. In contrast to PD-L1 expression, PD-L2 is restricted largely to APCs and it is inducibly expressed on ...
Tumor-associated macrophages (TAMs) are the predominant cells that express programmed cell death ligand 1 (PD-L1) within human tumors in addition to cancer cells, and PD-L1+ TAMs are generally thought to be immunosuppressive within the tumor immune microenvironment (TIME). Using single-cell transc...
normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to...
B7-H1 is mediated largely by one or more receptors other than PD-1. In addition, expression ...
Immunohistochemical analysis of programmed death receptor 1 (PD-L1) expression in Xp11.2 RCC. (A,B) Tumor sections with (A) positive, and (B) negative PD-L1 expression (magnification, ×200). Note that PD-L1 protein is expressed on the cell membrane as well as the in the cytoplasm of ...
Preclinical studies demonstrated that radiation up-regulates PD-L1 expression in tumor cells, providing a rationale for combining PD-1/PD-L1 inhibitors with radiation. However this has not been validated in patients with non-small cell lung cancer due to the difficulty to obtain serial biopsies. ...