文献阅读——PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program goblin7 20508 2 人赞同了该文章 目录 收起 1. Background 1.1作者简介 1.2 相关背景 2. Methods 3. Results 关键词: 联合治疗、PD-1、 IL-2、 CD5 1. Background 1.1作者简介 这篇文章是由美国埃默里大学...
他专注于记忆性T细胞的分化、T细胞及B细胞的抗病毒免疫机制的研究，发表于Nature、Science、Cell、Nature immunology、Immunity等顶级期刊的论文超过50篇，是CD8+ T细胞领域的专家。PD-1全称为Cell Death protein，扮演着在抑制免疫反应和促进自我耐受方面的关键角色。PD-1通过调节T细胞活性、激活抗原特异性T细...
[1] Chowdhury P S , Chamoto K, Honjo T . Combination therapy strategies for improving PD-1 blockadeefficacy: A new era in cancer immunotherapy[J]. Journal of Internal Medicine,2017.[2] Xu J , Wang Y , Shi J , et al. Combination therapy: A feasibility strategy for CAR-Tcell therap...
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program. Nature. 2022 Oct;610(7930):173-181. doi: 10.1038/s41586-022-05257-0. Epub 2022 Sep 28. PMID: 36171288. Codarri Deak L, et al. PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T ...
A combination therapy comprising antibody molecules that specifically bind to PD-1 is disclosed. Combination therapy may be used for treatment or prevention of cancerous or infectious conditions and disorders.グレンドラノフゴードンジェイムズフリーマン...
[30]HE AR, YAU T, HSU C, et al. Nivolumab (NIVO) + ipilimumab (IPI) combination therapy in patients (pts) with advanced hepatocellular carcinoma (aHCC): Subgroup analyses from CheckMate 040[J]. J Clin Oncol, 2020, 38(4 Suppl): 512.[31]KELLEY RK, SANGRO B, HARRIS WP, et al. ...
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic choriomeningitis virus infection1. Here we examine the underlying basis for this synergy. We show that PD-1 + IL-2 combination therapy, in contrast to PD-1 monotherapy, substantially changes the differen...
2022年9月28日,来自Emory 大学的Rafi Ahmed团队在Nature上发表题为PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program的文章。本文揭示了IL-2和PD-1阻断联合疗法的作用机制,为其应用于临床打下基础。 ...
参考资料 [1]Cheng X,et al.Successful Treatment of pMMR MSS IVB Colorectal Cancer Using Anti-VEGF and Anti-PD-1 Therapy in Combination of Gut Microbiota Transplantation: A Case Report. Cureus. 2023 Jul 24;15(7):e42347.https://pmc.ncbi.nlm.nih.gov/articles/PMC10445052/ ...
IL-2（ NCT03835533，NCT03138889）、IL-15（NCT02452268：A Phase I/Ib Study of NIZ985 in Combination With PDR001 in Adults With Metastatic Cancers）。简评：PD-1算是肿瘤治疗百年难遇的神药，后PD-1时代，基于PD-1/PD-L1的联合治疗是药物开发及临床使用的重点。但联合治疗的一个主要问题：毒性...主...