探索潜在的PD-L1调节因子有助于选择患者并克服对α-PD-1/PD-L1治疗的耐药性。此外,调节PD-L1表达的药物可能是目前免疫检查点抑制剂的辅助治疗方法。 参考文文献:Yi M, Niu M, Xu L, Luo S, Wu K. Regulation of PD-L1 expression in the tumor microenvironment. J Hematol Oncol. 2021 Jan 7;14(1)...
PD-1/PD-L1通路阻断剂，包括PD-1单克隆抗体(纳武单抗nivolumab,帕博丽珠单抗pembrolizumab，西米单抗cemiplimab)以及PD-L1单克隆抗体(阿特珠单抗atezolizumab,阿维鲁单抗avelumab,德瓦鲁单抗durvalumab)是包括黑色素瘤、乳腺癌、结直肠癌、非小细胞肺癌、小细胞肺癌、肾细胞癌、皮肤鳞状细胞癌以及血液系统肿瘤在内的多种...
[15] Zhou YJ, Li G, Wang J, et al. PD-L1: expression regulation. Blood Sci. 2023;5(2):77-91. Published 2023 Jan 13. doi:10.1097/BS9.0000000000000149 [16] Patel SP, Kurzrock R. PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy. Mol Cancer Ther. 2015;14(4):847-...
Introduction: Programmed cell death-ligand 1 (PD-L1) is a biomarker for prediction of the clinical efficacy of immune checkpoint inhibitors in various cancer types. The role of cytokines in regulation of PD-L1 expression in tumor cells has not been fully characterized...
程序性细胞死亡蛋白1(programmed cell death protein 1,PD-1)/程序性死亡配体1(programmed death-ligand 1,PD-L1)是导致肿瘤免疫逃逸的重要免疫检查点分子,阻断PD-1/PD-L1可以重新激活细胞毒性T细胞对肿瘤的杀伤作用,是一种重要的肿瘤免疫治疗方式。肿瘤细胞中PD-L1的表达可能影响抗PD-1/PD-L1治疗的临床疗效。
However, as there is limited information on how programmed death ligand-1 is upregulated on tumor cells within the tumor microenvironment, we examined the mechanism of programmed death ligand-1 regulation with a particular focus on interferon gamma in an invitro setting and in clinical samples. ...
5.Kowanetz M, Zou W, Gettinger S N, et al. Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)[J]. Proceedings of the National Academy of Sciences, 2018, 115(43): E10119-E10126.6.Garon E B, ...
程序性细胞死亡蛋白1(programmed cell death protein 1,PD-1)/程序性死亡配体1(programmed death-ligand 1,PD-L1)是导致肿瘤免疫逃逸的重要免疫检查点分子,阻断PD-1/PD-L1可以重新激活细胞毒性T细胞对肿瘤的杀伤作用,是一种重要的肿瘤免疫治疗方式。肿瘤细胞中PD...
Up-regulation of PD-L1 expression promoted the proliferation of EoL-1. At 48 and 72 h after seeding, the proliferation rate of OE-PD-L1 group was significantly higher than that of the vector group. (E) Knockdown of PD-L1 expression promotes cell apoptosis in KG-1a cell lines. (F) ...
the cell-surface expression of PD-L1. Consistently, western blot analysis showed that the PD-L1 level increased by the PS treatment but decreased by the Sph treatment (Fig.1g). In accordance, the ubiquitination of endogenous PD-L1 that was substantially decreased after the PS treatment increased...