中文名称:PD-L1稳定细胞系 英文名称:PD-L1 Stable Cell Line 品牌: 百普赛斯 产地: 北京 保存条件: Frozen in liquid nitrogen 纯度规格: 99.9% 产品类别: 细胞株/细胞系 别名: PD-L1 Stable Cell Line 货号: PD-L1 Stable Cell Line 用途范围: 生物 是否进口: 否 CHO/Human PD-L1 Stable Cell Line (...
CTLA-4抑制剂——Y药主要作用于T细胞的活化阶段,可控制初始T细胞(包括记忆性T细胞)的活化,激活T细胞识别低亲合力抗原,增殖为效应T细胞,增加能够识别肿瘤的克隆数; 而PD-1抑制剂——O药主要作用于T细胞的效应阶段,直接阻断肿瘤细胞上的程序性死亡配体1(PD-L1)和T细胞上PD-1结合,解除肿瘤细胞的免疫“刹车”作用,重...
产品名称Human PD-L1 & CD3L CHO Cell Line 货号:XHA122规格:5E6 cells/vial 品牌:价格:￥20010 产品分类:过表达细胞系研究领域:抗体药研发 CAS编号:N/A分子量:N/A 分子式:N/A别名:人PD-L1 & CD3L CHO过表达细胞系 储存条件:液氮运输条件:干冰 ...
[6] Perol, M., E. Felip, U. Dafni, et al., Effectiveness of PD-(L)1 inhibitors alone or in combination with platinum-doublet chemotherapy in first-line (1L) non-squamous non-small-cell lung cancer (Nsq-NSCL...
ThisExample demonstrated that the bispecific anti-humanPD-1/LAG-3Nanobodies F023700931 and F023700924 bound to both humanPD-1andhuman LAG-3 expressed by the T-cell line, blockedPD-1'sinteraction with PD-L1, blocks LAG-3's interacti...
细胞程序性死亡-配体1(Programmed cell death 1 ligand 1,PD-L1)是人类体内的一种蛋白质,由CD274基因编码。目前涉及到比较成型的药物主要是针对PD-L1的单克隆抗体,在多个肿瘤治疗领域取得突破性进展,如肺癌、黑色素瘤、淋巴瘤、肠癌等,有一定的治疗地位。
Effectiveness of PD-(L)1 inhibitors alone or in combination with platinum-doublet chmotherapy in first-line (1L) non-squamous non-small-cell lung cancer (Nsq-NSCLC) with PD-L1-high expression using real-world data. Ann Oncol. 2022 May;33(5):511-521....
PD-1/PD-L1 neutralizing antibodies block PD-1:PD-L1 interaction and promote T cell activation, resulting in reactivation of the NFAT responsive luciferase reporter. This product has been cited 11 times. Purchase of this cell line is for research purposes only; commercial use requires a separate...
L1 antibody. Strikingly, MC38 tumors grew in DC-conditional PD-L1 knockout mice did not respond to PD-L1 blockade therapy at all (Fig.2a). Another tumor model, E.G7, failed to respond to anti-PD-L1 as well (Supplementary Fig.3a). A central role of DCs in T cell activation is ...
2021年12月发表于 cell子刊Cancer Cell(IF=31.743)上的“Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer”; PD-1/PD-L1研究联合单细胞测序 在三阴性乳腺癌(TNBC)中,联合化疗和检查点抑制剂的作用机制尚未明确。在本篇文章中,...