NUS Scientists use Patient Derived Cancer Cell Culture to Predict Survival and Treatment OutcomeThe disclosure relates to the enrichment and expansion of rare cells in blood such as circulating tumor cells (CTCs), cancer stem cells [CSCs] and other rare circulating cells. The microwells promote ...
Here, we report an integrated pharmacogenomic analysis of 100 patient-derived GBM cell cultures from the human glioma cell culture (HGCC) cohort. Exploring 1,544 drugs, we find that GBM has two main pharmacological subgroups, marked by differential response to proteasome inhibitors and mutually ...
Williams SA, Anderson WC, Santaguida MT, Dylla SJ (2013) Patient-derived xenografts, the cancer stem cell paradigm, and cancer pathobiology in the 21st century . Laboratory Investigation 93 : 970–982doi: 10.1038/labinvest.2013.92Williams SA, Anderson WC, Santaguida MT, Dylla SJ. Patient-...
Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution Serena Mazzucchelli Lorena Signati Fabio Corsi Cancer Cell International(2024) Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine ...
CellMiner Cross-Database (CellMinerCDB, discover.nci.nih.gov/cellminercdb) allows integration and analysis of molecular and pharmacological data within and across cancer cell line datasets from the National Cancer Institute (NCI), Broad Institute, Sanger/MGH and MD Anderson Cancer Center (MDACC). We...
Organoids (and cancer-derived organoids), are three-dimensional tissue-resembling cellular clusters derived from tissue or tumor specific stem cells that mimic the in vivo (tumor) characteristics, as well as (tumor) cell heterogeneity. Cancer organoids may further enhance the in vitro and in ...
Cancer stem cells (CSCs) are responsible for the resistance of osteosarcoma to chemotherapy and OCT4, SOX2 and SSEA4 have been used to identify CSCs in osteosarcoma. Here, we used low-passage patient-derived osteosarcoma cells and osteosarcoma cells directly isolated from patients before and after...
BackgroundPatient-derived tumor xenograft models have been established and increasingly used for preclinical studies of targeted therapies in recent years. However, patient-derived non-small cell lung cancer (NSCLC) xenograft mouse models are relatively few in number and are limited in their degree of...
Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts. Molecular oncology. 2014;8:656-68... Monique D. Topp a b,Lynne Hartley a,Michele Cook a,... - 《Molecular Oncology》 被引量: 95发表: 2014年 Neuroblastoma patient-derived orthotopic...
IL-2, IL-4, IL-7, IL-9, IL-15 and, IL-21, which cause the loss of immune cells B, T, and NK, so these rodents are essential for transplantation of primary human tumors, while other immunocompromised mice are suitable for the development of cancer cell line-derived models [60,61]...