Adult stem cell–based organoid technology is a versatile tool for the generation and long-term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer organoids from primary patient material enables a range of therapeutic age
BMC CancerWang H, Lu J, Tang J, et al. Establishment of patient⁃derived gastric cancer xenografts: a useful tool for preclinical evaluation of targeted therapies involving alterations in HER - 2, MET and FGFR2 signaling pathways [ J] . BMC Cancer, 2017, 17 ( 1 ) : 191....
BackgroundPatient-derived tumor xenograft models have been established and increasingly used for preclinical studies of targeted therapies in recent years. However, patient-derived non-small cell lung cancer (NSCLC) xenograft mouse models are relatively few in number and are limited in their degree of...
P-292 Establishment of patient-like SCID mice model by orthotopically implanting lung cancer cell lines - Lung Cancerdoi:10.1016/S0169-5002(03)92260-4Haruhiko FujinoKazuya KondoTakanori MiyoshiHisashi IshikuraYasumasa MondenElsevier Ireland LtdLung Cancer...
Establishment and characterisation of patient-derived xenografts as paraclinical models for gastric cancer The patient-derived xenograft (PDX) model is emerging as a promising translational platform to duplicate the characteristics of tumours. However, few studies have reported detailed histological and ...
ovarian cancerpatient‐derived xenograftAim: Malignant transformation of mature cystic teratoma (MTMCT) of the ovary is a rare gynecological malignancy and commonly arises in women older than 50 years of age. The most common histological type of MTMCT is squamous cell carcinoma (SCC), and the ...
A significant gap in pancreatic ductal adenocarcinoma (PDAC) patient's care is the lack of molecular parameters characterizing tumours and allowing a personalized treatment. Methods Patient-derived xenografts (PDX) were obtained from 76 consecutive PDAC and classified according to their histology into fiv...
Current evidence indicate that cancer-associated fibroblasts (CAFs) play an important role in prostate cancer (PCa) development and progression. In this study, we identified CAF-related molecular subtypes and prognostic index for PCa patients undergoing
Therefore, we believe that our established method becomes a promising research model for studying patient-derived cancer cells. The difference of the media components between the 2.5D and 3D BC organoids was presented in Table 1. The presence of 5% FBS and EGF in the 2.5D media promoted cell...
Our 3D culture system with patient-derived tissue-specific decellularized ECM better recapitulates the pancreatic cancer microenvironment compared to conventional 2D culture conditions and represents a relevant approach for the study of pancreatic cancer response to chemotherapy agents....