Adult stem cell–based organoid technology is a versatile tool for the generation and long-term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer organoids from primary patient material enables a range of therapeutic age
Establishment of patient⁃derived gastric cancer xenografts: a useful tool for preclinical evaluation of targeted therapies involving alterations in HER - 2, MET and FGFR2 signaling pathways [ J] . BMC Cancer, 2017, 17 ( 1 ) : 191.
BackgroundPatient-derived tumor xenograft models have been established and increasingly used for preclinical studies of targeted therapies in recent years. However, patient-derived non-small cell lung cancer (NSCLC) xenograft mouse models are relatively few in number and are limited in their degree of...
P-292 Establishment of patient-like SCID mice model by orthotopically implanting lung cancer cell lines - Lung Cancerdoi:10.1016/S0169-5002(03)92260-4Haruhiko FujinoKazuya KondoTakanori MiyoshiHisashi IshikuraYasumasa MondenElsevier Ireland LtdLung Cancer...
A prerequisite for the development of new drugs is the availability of relevant tumor models for preclinical testing. In the last years, patient derived xenograft (PDX) models have proven to be more relevant for drug screening and ... J Hoffmann,A Orthmann,A Hoffmann,... - 《Cancer Research...
malignant transformation of mature cystic teratomaovarian cancerpatient‐derived xenograftAim: Malignant transformation of mature cystic teratoma (MTMCT) of the ovary is a rare gynecological malignancy and commonly arises in women older than 50 years of age. The most common histological type of MTMCT ...
Current evidence indicate that cancer-associated fibroblasts (CAFs) play an important role in prostate cancer (PCa) development and progression. In this study, we identified CAF-related molecular subtypes and prognostic index for PCa patients undergoing
A bladder cancer cell line was derived from a female Chinese patient with muscle-invasive bladder cancer, and these cells were then xenografted into the bladders of three nude mice. Five weeks later, these mice were killed to observe local invasion and distant metastasis. The metastatic tumors ...
Our 3D culture system with patient-derived tissue-specific decellularized ECM better recapitulates the pancreatic cancer microenvironment compared to conventional 2D culture conditions and represents a relevant approach for the study of pancreatic cancer response to chemotherapy agents....
In this study, we successfully established a novel gallbladder cancer cell line, designated as GBC-X1, derived from a primary tumor of a gallbladder cancer patient. By comprehensively analyzing the cell line's phenotype, molecular characteristics, biomarkers, and histological characteristics, we confir...