Patient-Derived Primary Cells in High-Throughput Differential Antitumor ScreensPharmaceutical sciencePreformulationDrugFormulationCandidate Drug SelectionBiopharmaceuticalDosage FormsTransdermalDrug DeliveryDrug DiscoveryPaul Ehrlich's pioneering work in 1905, which culminated in the discovery of arsephenamine (also ...
Towards this goal, we have established a compilation of pharmacological landscapes of 462 patient-derived tumor cells (PDCs) across 14 cancer types, together with genomic and transcriptomic profiling in 385 of these tumors. Compared with the traditional long-term cultured cancer cell line models, ...
‘functional cellular endophenotypes’) in a variety of patient-derived cells, such as induced pluripotent stem cell (iPSC)-derived neurons and organoids or peripheral blood mononuclear cells (PBMCs). Disease-specific alterations in cellular responses can subsequently yield novel drug screening targets ...
However, only one TGCT cell line is currently available from cell banks, and a paucity of adequate patient-derived cells hinders basic and translational research. This study aimed to establish a novel cell line of TGCT. To this end, a novel cell line, NCC-TGCT1-C1 was established from the...
comboFM is a machine learning framework for predicting the responses of drug combinations in pre-clinical studies, such as those based on cell lines or patient-derived cells, implemented in Python. The data used in the experiments is available on:https://zenodo.org/record/3782333#.XyA-xx1RX...
Tumour growth data was also collected from two allografts of murine colorectal cancer (CT26) and B-cell lymphoma (A20) cells. Results and discussions Colorectal PDX tissue was comparable between the R2G2 and the NSG mouse models, however the standard error was much lower in the R2G2 strain....
After 3 to 5 days, the organoids were dissociated by using accutase (Gibco BRL) to the single cells and prepared to load on the micropillar chip. 40 nl droplet for cell/alginate mixture and 950 nl for media or compounds were dispensed with S + microarrayer (S + Chip Scanner, Samsung ...
cells, which effectively inhibited the tumor [57]. Another application of PDX models in cell therapy is assessing various aspects of CAR-T cell treatment and biology. One of these aspects is the interaction between CAR-T and other immune cells such as Tregs and Myeloid-Derived Suppressor Cells...
Abstract 4315: Enrichment of xenotransplantable clonal cells in CD38high/CD138+ cells of multiple myeloma patients Multiple myeloma is a plasma cell neoplasm characterized by frequent relapse following initial therapy, implying the presence of a therapy-resistant and tumor-initiating cell population. Whil...
Parkinson’s disease (PD) is the second most prevalent neurological disorder and has been the focus of intense investigations to understand its etiology and progression, but it still lacks a cure. Modeling diseases of the central nervous system in vitro with human induced pluripotent stem cells (...