We confirm this trend in cell and in xenotransplantation models, and identify both Bcl-2 family inhibitors and p53 activators as potentiators of proteasome inhibitors in GBM cells. We can further predict the responses of individual cell cultures to several existing drug classes, presenting ...
Schizophrenia-associated differences in the DNA methylation status of patient-derived cells suggest it could affect early brain development. Mechanisms that control gene expression without altering the genetic code, such as DNA methylation, could explain how environmental risk factors contribute to ...
discovery which aims to address these limitations by identifying disease-related functional responses (‘functional cellular endophenotypes’) in a variety of patient-derived cells, such as induced pluripotent stem cell (iPSC)-derived neurons and organoids or peripheral blood mononuclear cells (PBMCs)....
The stem cell/cancer stem cell marker ALDH1A3 regulates the expression of the survival factor tissue transglutaminase, in mesenchymal glioma stem cells Tissue transglutaminase (tTG), a dual-function enzyme with GTP-binding and acyltransferase activities, has been implicated in the survival and chemother...
Induced pluripotent stem cells (iPSCs) are embryonic stem cell-like cells reprogrammed from somatic cells by four transcription factors, OCT4, SOX2, KLF4 and c-MYC. iPSCs derived from cancer cells (cancer-iPSCs) could be a novel strategy for studying cancer. During cancer cell reprogramming, ...
INVITED SPEAKERS; PATIENT-DERIVED STEM CELL MODELS OF BRAIN DISEASES: NEW TOOLS FOR DRUG DISCOVERY There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells req... SA Mackay 被引量: 0发表: 2010年 ...
instead of having to retrieve cells from the tumour itself. Results of the tests on these CTCs could help doctors assess the best therapy options for a patient, and frequent blood tests can also be done during the course of an anti-cancer treatment to provide a real-time monitoring of a ...
In our report, we have established six patient-derived cancer cells (PDCs) from NSCLC patients who were treated with various TKIs and thereafter experienced disease progression. The success rate for PDCs was as high as 50% (6/12). Upon the established cell lines, 2 cases had EML4-ALK and...
Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells The emergence of human induced pluripotent stem cell (hiPSC) technology has allowed researchers to work with SZ patient-derived neuronal and glial cell ... U Dubonyte,A Asenjo-Martinez,T Werge,... -...
Glioblastoma stem- like cells (GSCs) are able to migrate in vascular niches within or away from the tumour mass, increasing tumour resistance to patient treatments and contributing to relapses. To study individual GSCs migration and their interactions with the microenvironment in the vasculature, ...