Schizophrenia-associated differences in the DNA methylation status of patient-derived cells suggest it could affect early brain development. Mechanisms that control gene expression without altering the genetic code, such as DNA methylation, could explain how environmental risk factors contribute to ...
Towards this goal, we have established a compilation of pharmacological landscapes of 462 patient-derived tumor cells (PDCs) across 14 cancer types, together with genomic and transcriptomic profiling in 385 of these tumors. Compared with the traditional long-term cultured cancer cell line models, ...
However, only one TGCT cell line is currently available from cell banks, and a paucity of adequate patient-derived cells hinders basic and translational research. This study aimed to establish a novel cell line of TGCT. To this end, a novel cell line, NCC-TGCT1-C1 was established from the...
Tumour growth data was also collected from two allografts of murine colorectal cancer (CT26) and B-cell lymphoma (A20) cells. Results and discussions Colorectal PDX tissue was comparable between the R2G2 and the NSG mouse models, however the standard error was much lower in the R2G2 strain....
Tumor-killing activity of the CD19-targeting CAR T cells was assessed by co-culturing the CAR T cells with MCL organoids. Conclusion We have established an MCL PDO platform which is time-efficient, labor-saving, cost-effective and highly reproducible. This platform provides a rapid approach ...
comboFM is a machine learning framework for predicting the responses of drug combinations in pre-clinical studies, such as those based on cell lines or patient-derived cells, implemented in Python. The data used in the experiments is available on:https://zenodo.org/record/3782333#.XyA-xx1RX...
However, it is important to note that human stromal cells are gradually replaced by murine counterparts after transplantation into immunodeficient mice, which suggests that implanted human cancer cells retain the potential to recruit murine stromal cells to their niche. Importantly, there are some diffe...
cells, which effectively inhibited the tumor [57]. Another application of PDX models in cell therapy is assessing various aspects of CAR-T cell treatment and biology. One of these aspects is the interaction between CAR-T and other immune cells such as Tregs and Myeloid-Derived Suppressor Cells...
However, we identified molecular targeting reagents, such as bortezomib and crizotinib that markedly suppressed the growth of CDS cells. Our models will be useful modalities to develop novel therapeutic strategies against CDS. 展开 关键词: Cancer models Cancer screening Sarcoma ...
discovery which aims to address these limitations by identifying disease-related functional responses (‘functional cellular endophenotypes’) in a variety of patient-derived cells, such as induced pluripotent stem cell (iPSC)-derived neurons and organoids or peripheral blood mononuclear cells (PBMCs)....