EXTRACELLULAR matrixNEOVASCULARIZATIONQUALITY of lifeChronic nonhealing wounds significantly reduce patients' quality of life and are a major burden on healthcare systems. Over the past few decades, tissue engineering materials have emerged as a viable option for wound healing, with cell-...
The future of tissue engineering applications for neuronal cells will require a supportive 3D matrix. This particular matrix should be soft, elastic and su... L Ylä-Outinen,T Joki,M Varjola,... - 《Journal of Tissue Engineering & Regenerative Medicine》 被引量: 31发表: 2012年 Methods to...
Extracellular matrix Decellularized Chondrocytes IL-1β TNF-α SIRT1 1. Introduction Articular cartilage has a limited capacity for intrinsic repair due to its avascular and aneural structure. Chondrocytes, the only cell type residing in cartilage, play a major role in maintaining cartilage homeostasis...
CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERK and NF-B signalling pathways in odontoblast cells.###Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome ... Our findings also indicate that platelet-derived IL-1 is chief...
Extracellular microparticles (MPs) can function as drug-delivery vehicles for anticancer drugs. Here, we show that the softness of MPs derived from tumour-repopulating cells (TRCs) isolated from three-dimensional fibrin gels enhances the MPs’ drug-deliv
Previously, 3D human cardiac tissues have been engineered using scaffold-free cell sheets, synthetic polymer scaffolds, various hydrogels (including collagen, fibrin, and cardiac-derived matrix), and decellularized tissues6. Even with the use of electrical and mechanical stimulation, these tissues exhibit...
(ILVs) that make up MVBs have two destinies: degradation due to delivery to the lysosomal lumen or secretion into surrounding extracellular matrix as exosomes through fusion with the plasma membrane [178]. These results emphasize the role of exosomes in the development of AD through the spread ...
Receptors of the integrin family are expressed by every cell type and are the primary means by which cells interact with the extracellular matrix. The cont... ML Condic,PC Letourneau - 《Nature》 被引量: 352发表: 1997年 Cell-extracellular matrix interactions regulate neural differentiation of hum...
In wound healing, different cell types precisely work together to coordinate the biological and molecular events of cell migration, proliferation, and extracellular matrix (ECM) remodeling [1]. Particularly, in chronic wounds, where the healing process may stall at various phases, the regular successi...
Top right, n = 506 structures from 3 independent experiments for lumen and extracellular matrix (ECM) efficiency. Bottom right, n = 27 embryoids from 2 independent experiments for lumen number. g,h, Inner domains of embryoids are surrounded by a dashed line. d,e,h, Data are ...