Cell-derived decellularized extracellular matrix (DECM) has been used as a culture substrate for mesenchymal stem cells (MSCs) to improve the cell proliferation and lineage-specific differentiation. In this study, DECM deposited by synovium-derived MSCs was used as an in vitro expansion system for...
The human embryo undergoes morphogenetic transformations following implantation into the uterus, but our knowledge of this crucial stage is limited by the inability to observe the embryo in vivo. Models of the embryo derived from stem cells are important
Matrix near the cell body was pulled anterograde, suggesting a contractile axis between the leading and trailing edges. Altogether, these data indicate that different matrix architectures can influence cell migration rates, though fibroblasts employ a similar migratory process for pulling the cell body ...
然而,我们对被激活的内源TM细胞了解极其有限,严重限制了青光眼受损组织新型再生方法的研发。 近日,青岛大学药学院朱玮教授团队在Cell Proliferation上发表了题为“iPSC-derived cells stimulate ABCG2+/NES+ endogenous trabecular meshwork cell proliferation and tissue regeneration”的文章。该研究揭示iPSC-TM促进TM组织...
近日，同济大学岳锐教授团队在生物学顶刊《Cell》子刊上发表文章，展示了一种或许是最简单逆转造血干细胞衰老的方法：不吃药不禁食，坐等造血干细胞自己重返青春[1]！干细胞能够不断自我更新并分化成各种功能细胞，维持或修复机体组织，是人类身体里维系生命的中坚力量[2]。而造血干细胞，顾名思义，其最主要工作就是...
Besides the changes in phenotypic characteristics, the viability, proliferation, migration, mesenchymal marker expression, and changes in the extracellular matrix components were also evaluated. ResultsOur study clearly demonstrates that when cell line-derived RPE cells (unlike donor-derived RPE cells), ...
GO enrichment analysis revealed that these key genes are mainly distributed in the extracellular matrix and spindle and participate in the cell processes such as chromatid separation, cell cycle, mitosis, etc. By binding with chemokine receptors or regulating protein kinase (Fig. 2C-E). In ...
Anderson and Chaplain (1998). They proposed a continuous model for tumor-induced angiogenesis, and derived from that a discrete, stochastic model simulating the motility of ECs. Their model simulates migration of endothelial cells from a parent vessel toward a tumor, which chemotact along a ...
Another microfluidic device was designed in order to enable the common culture of hiPSC-derived cardiomyocytes and endothelial cells within one device in such a way that hiPSC-CMs grow in 3D matrix in the central part of the chip and hiPSC-derived endothelial cells are seeded into two lateral ...
Next, to capture the chromatin configuration in specific cell types, we fit the gene expression derived from scRNA-seq data with XGBoost regression models13 using the integrated sequence information. Both of the used sequence and regression model are found to be suited for this application in the...