Over the past few decades, tissue engineering materials have emerged as a viable option for wound healing, with cell-derived extracellular matrix (CDM) showing remarkable results. The CDM's compatibility and resemblance to the natural tissue microenvironment confer distinct advantages to ...
Given the important role of HK1 in glycolysis, we tested whether LX-2 cell–derived lEV HK1 can promote glycolysis in HCC cells. Glucose uptake and the extracellular acidification rate (ECAR) in Huh7 and HepG2 cells were clearly elevated upon incubation with lEVs from control cells but not w...
Decellularized extracellular matrices show 邪 great promise as materials for tissue engineering and regenerative medicine. Recently, there has been an incr... R Ushakov - 《Cell & Tissue Biology》 被引量: 0发表: 2023年 Cultured cell-derived decellularized extracellular matrix: future applications and...
Recent studies have also examined the effect of miRNAs in MSC-EVs. In synovial-derived MSC-EVs (SMSC-EVs), Tao et al. overexpressed miR-140-5p to block Wnt5a and Wnt5b to activate YAP via the Wnt signaling pathway and significantly reduce extracellular matrix (ECM) secretion [91]. Wang ...
The skin is privileged because several skin-derived stem cells (epithelial stem cells from epidermis and its appendages, mesenchymal stem cells from dermis and subcutis, melanocyte stem cells) can be efficiently captured for therapeutic use. Main indications remain the permanent coverage of extensive ...
研究意义：组织纤维化和并发的胞外基质（Extracellular matrix，ECM）变硬与肝细胞癌、胰腺导管腺癌和乳腺癌等癌症进展有关。已知高硬度ECM可促进细胞增殖、上皮间质转化、迁移和化学耐药，这与胞外基质硬度增加导致细胞所受张力增加有关。具体机制则是细胞膜中的整合素蛋白（Integrins）感应ECM硬度，通过调节细胞黏附分子...
Recently, decellularized cell-derived extracellular matrix (DECM) has attracted attention in cartilage tissue engineering because it greatly promotes the chondrogenic differentiation capacity of mesenchymal stem cells (MSCs) [13]. Intra-articular injection of DECM-expanded MSCs successfully repaired partial-...
3. EV还可以促进前肿瘤基质细胞的分化或募集[纤维母细胞(Fibroblasts)和骨髓来源细胞(Bonemarrow-derived cells,BMDC)]。反过来,周围纤维母细胞分泌的EV复杂的相互作用可以增强肿瘤细胞迁移能力及耐药性。 4. 此外,小EV还能进入循环,从原发肿瘤到达远端位点(见上图右)。小EV的货物能增加血管通透性,EV可以进入远端组织...
相关研究结果于2023年1月12日在线发表在Cell Stem Cell期刊上,论文标题为“Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons”。 虽然以前的科学家们已将干细胞分化为神经元,但这些神经元在功能上是不成熟的---类似于胚胎或出生后早期的神经元。
Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling 认领 被引量:3 引用 收藏 分享 摘要 The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing ...展开更多 作者 ...