Extracellular matrix (ECM) biology, which includes the functional complexities of ECM molecules, is an important area of cell biology. Individual ECM protein components are unique in terms of their structure, composition and function, and each class of ECM macromolecule is designed to interact with ...
Biology of Extracellular Matrix SeriesELSEVIERExtracellular Matrix Assembly and Structure
Collagens form a family of extracellular matrix proteins that is often associated with metazoan multicellularity and evolution. These modular proteins elaborate supramolecular networks that contribute to the physical and biological properties of tissues. Among the different collagen families characterized in ve...
Extracellular Matrix Components of the Synapse Blood Vessel Proteoglycans Heparan Sulfate Species and Blood Vessel Wall Function Cell-Associated Proteoglycans in Human Malignant Melanoma Intracellular Proteoglycans in Cells of the Immune System Index
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研究意义：组织纤维化和并发的胞外基质（Extracellular matrix，ECM）变硬与肝细胞癌、胰腺导管腺癌和乳腺癌等癌症进展有关。已知高硬度ECM可促进细胞增殖、上皮间质转化、迁移和化学耐药，这与胞外基质硬度增加导致细胞所受张力增加有关。具体机制则是细胞膜中的整合素蛋白（Integrins）感应ECM硬度，通过调节细胞黏附分子...
1Michel, Gurvan; Thierry Tonon; Delphine Scornet; J. Mark Cock; Bernard Kloareg (October 2010). “The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes”. New Phytologist 188 (1): 82–97...
It also shows that microvesicles but not exosomes carry metalloproteases able to digest the extracellular matrix. CAS PubMed PubMed Central Google Scholar Wang, T. et al. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. ...
Cell - Matrix, Proteins, Biology: Matrix proteins are large molecules tightly bound to form extensive networks of insoluble fibres. These fibres may even exceed the size of the cells themselves. The proteins are of two general types, structural and adhes
This special issue is focused on roles for the extracellular matrix or its integrin receptors in the cell’s ability to dynamically regulate the tissue microenvironment in normal or pathological processes, including through control of the secretome … ...