extracellular matrix are: cell adhesion molecules, or “CAMs,” which are age- and tissue-specific, and proteoglycans, molecules containing a protein core to which polymers of sulfated (negatively charged) sugars called glycosaminoglycans (e.g., heparan sulfates, heparins, chrondroitin sulfates, or...
Choose Cultrex: An Extracellular Matrix That Prioritizes Quality When you choose Cultrex BME matrices, you are choosing a quality reagent. Being able to trust in the efficacy of your starting materials gives your experiments the best chance of success. Cultrex's rigorous quality testing enables ...
Roger R. Markwald, in Heart Development and Regeneration, 2010 II.A The Extracellular Matrix The extracellular matrix of the endocardial cushions is a unique and dynamic mixture of proteins, glycosaminoglycans and proteoglycans that, at its origin, is devoid of any cells. The constituents of the...
Furthermore, the uptake of EVs from MDA-MB-231 cells by MCF10A cells induces regulatory changes in E-cadherin, secretion of matrix metalloproteinases (MMPs), and promotion of invasion [88]. Additionally, the reprogramming of cancer metabolism, an essential process for cancer progression, is facil...
The isolation of stromal vascular fraction was carried out as previously described [47]. Briefly, the extracellular matrix was incubated in Hank’s Balanced Salt Solution (Life Technologies Italia, Milan, Italy) with collagenase type I (Life Technologies Italia, Milan, Italy) and bovine serum album...
The extracellular matrix (ECM) is a dynamic environment that constantly provides physical and chemical cues to embedded cells. Much progress has been made in engineering hydrogels that can mimic the ECM, but hydrogel properties are, in general, static. To recapitulate the dynamic nature of the ECM...
The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr. Opin. Cell Biol. 20, 502–507 (2008). CAS PubMed Google Scholar Rana, S., Yue, S., Stadel, D. & Zoller, M. Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection. ...
Finally, the paracrine secretome was characterized as a function of matrix remodeling through gene and protein expression and conditioned media studies. Results The decellularized infarct tissue revealed significant alterations in both the mechanical and compositional properties of the ECM with remodeling ...
Consequently, redundant regulatory mechanisms are in place ensuring that tissue remodeling terminates once matrix homeostasis is re-established. If these mechanisms fail, stromal cells become continuously activated, accumulate excessive amounts of stiff matrix, and fibrosis develops. In this mini-review, ...
The most prominent binding partners of hyaluronan in the nervous system are the extracellular matrix proteoglycans of the lectican family (also called hyalectans) (reviewed by Bandtlow and Zimmermann2000; Iozzo and Murdoch1996; Rauch2004; Ruoslahti1996; Yamaguchi2000). In mammals, four distinct le...