e16610#Background:Non-muscle invasive bladder cancer (NMIBC) has a high recurrence and progression rate, and the intravesical instillation chemotherapy drugs is diverse. To optimize patient prognosis, patient-derived tumor-like cell clusters (PTC) for drug testing seeks to identify an effective drug...
Importantly, cell proliferation by the CR method is reversible, with removal from the growth-stimulating conditions generally leading to differentiation of these stem-like cells to their committed fate. Primary tumor cells expanded in CR cultures have been shown to maintain the characteristics of the ...
Like c-MET, RON is expressed by a variety of epithelial-derived tumors and cancer cell lines ... DL Ludwig,KE Rabenau,DJ Hicklin,... - 《Cancer Research》 被引量: 280发表: 2006年 Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms...
Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has broadened the repertoire of preclinical models and progressively revolutionized three-dimensional cell culture in oncology. PDTO can be grown from patient tumor samples with high efficiency and faithfully recapitulates th...
spheroids [62]. Because there were cells positive for both E-cadherin and Vimentin, it is likely that partial EMT occurs in spheroids, the PDX model and the original tumor [62,65]. Single cancer cell migration, also known as mesenchymal migration, is characterized by fibroblast-like morphology...
tumor tissue had been reported to use for Xenograft model establishment; primary breast, pleural effusion, ascites, and metastatic sites like the ovarian, brain, Nodal, skin, and soft tissue. Statistically Controversial metastatic site was found between the PDX model and human tumor; bone and ...
tumor tissue had been reported to use for Xenograft model establishment; primary breast, pleural effusion, ascites, and metastatic sites like the ovarian, brain, Nodal, skin, and soft tissue. Statistically Controversial metastatic site was found between the PDX model and human tumor; bone and ...
Intra‐ and inter‐tumor heterogeneity in a vemurafenib‐resistant melanoma patient and derived xenografts The development of targeted inhibitors, like vemurafenib, has greatly improved the clinical outcome of BRAFV600E metastatic melanoma. However, resistance t... K Kemper,O Krijgsman,P Cornelissen-...
Many factors impact the success of PDX models, including the quality of the tumor sample, the choice of engraftment site, the use of immune-deficient mice, and the timing and method of engraftment [1]. In particular, the low engraftment rate of PDX models has been a major obstacle to ...
Derivation of cervical tumoroids from Pap brush material Introduction of the Pap test into the clinic has been instrumental in rapid early diagnosis of cervical abnormalities. As a result, the mortality rate of cervical cancer has declined significantly over the past few decades, predominantly in eco...