NK: Natural killer pDCs: Plasmacytoid dendritic cells mIHC: Multiple immunofluorescence PR: Partial response SD: Stable disease PD: Progressive disease THYM: Thymoma READ: Rectum adenocarcinoma DNMTs: DNA methylation transferases Tex: Exhausted CD8+ T cell ...
In the TCGA pan-cancer cohort, we used CIBERSORT to assess immune cell infiltration of tumor tissue. NK cells activated, monocytes, Tregs, B cells naive, T cells CD8, T cells CD4 memory resting, and macrophages M2 were lower in CDKN2A-MUT or DEL patients’ tumor tissue than in CDKN2A-WT...
They possess a broad anti-tumor activity at exceedingly low E:T ratios with specific production of IFN-纬, IL-6 and IL-8 during tumor cell killing. Ongoing efforts are underway to understand the relative contributions of NK cells, 纬未 T cells and CD8+ T cells to broad tumor cytolysis ...
showing that IL32 expression is significantly positively correlated with most immune cell subtypes in BRCA, SKCM, THCA, PRAD, BLCA, LUSC, TGCT, HNSC, LUAD, PCPG, UVM, KICH, CESC, DLBC, and significantly positively correlated with NK cells, CD4 + memory T-cells, CD8 + T cells...
NK cells and B cells originating from UCEC demonstrated unique features (Figure S7a), implying that the TMEs across diverse cancer types could have potentially exerted distinct effects on immune cell phenotypes. We subsequently investigated the heterogeneity of fibroblasts in scRNA-seq datasets of the...
Cancer cells employ various mechanisms to evade immune surveillance and avoid elimination by tumor-suppressing immune cells, which include NK cells, M1-polarized macrophages, and effector T cells5. Cancer immunotherapy, particularly the use of immune checkpoint inhibitors (ICIs) therapy, aimed at ...
Pearson's correlation test was used to determine the correlation between PNO1 expression and 18 T-cell subtypes, as well as 6 other immune cell types including B cells, NK cells, monocytes, macrophages, neutrophils, and dendritic cells (DC). Subsequently, a co-expression analysis of PNO1 ...
Abstract Large-scale, pan-cancer analysis is enabled by data driven knowledge bases that link tumor molecular profiles with phenotypes. A debilitating cancer-related phenotype is skeletal muscle loss, or cachexia, which occurs partly from tumor products secreted into circulation. Using the LinkedOmicsKB...
Pan-cancer upregulated PSGs (uPSGs) tend to promote tumors and to play cell cycle-related roles We next analyzed whether and how tumors benefit from upregulated PSGs by integrating survival data, pathway enrichment data, and gene essentiality data in cancer cell lines (“Methods”). To identi...
Peroxiredoxins (PRDXs) are an antioxidant enzymes protein family involved in several biological functions such as differentiation, cell growth. In addition, previous studies report that PRDXs play critical roles in the occurrence and development of carci